ReviewFrontiers in clinical diabetes and healthcare2021
Updates in the Management of Hyperglycemic Crisis.
Review in Frontiers in clinical diabetes and healthcare, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Delayed Emergence Due to Severe Respiratory Acidosis Following Prolonged Spine Surgery: A Case Report.Cureus · 2026Article
- Carbamazepine-induced acute generalized exanthematous pustulosis triggering diabetic ketoacidosis in a patient with type II diabetes mellitus: a case report.Annals of medicine and surgery (2012) · 2026Article
- Advances in Micro- and Macrobiological Strategies for Pest Control in Berry Production Systems: A Critical Review.Plants (Basel, Switzerland) · 2026Review
- Polyvinyl chloride-related insulin adsorption in critical care: a narrative review with implications for patient safety and green hospital reform.Frontiers in medicine · 2026Review
- Article
- A narrative review of the diabetic ketoacidosis and hyperosmolar hyperglycemic state overlap syndrome.International journal of emergency medicine · 2025Review
- A clinical model for highly accurate prediction of blood glucose depression after continuous intravenous insulin therapy in hyperglycemic emergencies, a multicenter retrospective cohort study.Journal of diabetes investigation · 2025Article
- Research Priorities for Diabetic Ketoacidosis: An Evidence and Gap Mapping Review.Medical sciences (Basel, Switzerland) · 2025Review
- Diagnostic Accuracy of End-Tidal Carbon Dioxide for Assessing Diabetic Ketoacidosis: A Systematic Review and Meta-Analysis.Archives of academic emergency medicine · 2025Article
- Quantifying the Deficits of Body Water and Monovalent Cations in Hyperglycemic Emergencies.Journal of clinical medicine · 2024Article
- The effect of renal function on the clinical outcomes and management of patients hospitalized with hyperglycemic crises.Frontiers in endocrinology · 2024Observational
- Diabetic Ketoacidosis among Diabetic Patients Admitted in the Department of Medicine of a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2023Article
- Overlap of diabetic ketoacidosis and hyperosmolar hyperglycemic state.World journal of clinical cases · 2022Review
- Hyperglycemia in Critically Ill Patients: Current Approaches and Management Strategies.In vivo (Athens, Greece)Review
- Alzheimer's disease model explains Alzheimer's disease incidences.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) affects the metabolism of primary macronutrients such as proteins, fats, and carbohydrates. Due to the high prevalence of DM, emergency admissions for hyperglycemic crisis, diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are fairly common and represent very challenging clinical management in practice. DKA and HHS are associated with high mortality rates if left not treated. The mortality rate for patients with DKA is < 1% and ~ 15% for HHS. DKA and HHS have similar pathophysiology with some few differences. HHS pathophysiology is not fully understood. However, an absolute or relative effective insulin concentration reduction and increased in catecholamines, cortisol, glucagon, and growth hormones represent the mainstay behind DKA pathophysiology. Reviewing the patient's history to identify and modify any modifiable precipitating factors is crucial to prevent future events. The aim of this review article is to provide a review of the DKA, and HHS management based on the most recently published evidence and to provide suggested management pathway of DKA of HHS management in practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.