ArticleJournal of Taibah University Medical Sciences2023
Effects of physical activity breaks during prolonged sitting on vascular and executive function-A randomised cross-over trial.
Article in Journal of Taibah University Medical Sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Acute cognitive effects of interruptions to prolonged sitting with brief standing or physical activity breaks: a systematic review and three-level meta-analysis.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Effect of breaking up prolonged sitting with physical activity on executive function: a three-level meta-analysis.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Acute effects of physical activity breaking up sedentary behavior on cognitive function, biological mechanisms, and practical recommendations: a systematic review.Frontiers in psychology · 2026Pooled it
- Effects of breaking up prolonged sitting on vascular endothelial function in adults: a systematic review.Frontiers in cardiovascular medicine · 2026Pooled it
- Evaluating the methods used to examine sitting breaks and their influence on mental load, physical strain, and cognitive performance - a scoping review.Frontiers in physiology · 2026Pooled it
- The Impact of Cocoa Flavanols in Modulating Resting Cerebral Blood Flow During Prolonged Sitting in Healthy Young and Older Adults.Nutrients · 2025Trial
- Impact of dietary fiber intake on insulin resistance in type 2 diabetes: A systematic review.Journal of education and health promotion · 2026Review
- Short bouts of accumulated exercise: Review and consensus statement on definition, efficacy, feasibility, practical applications, and future directions.Journal of sport and health science · 2025Article
- A short bout of low to moderate aerobic exercise influences cognitive performance in healthy adults based on task type, timing, and individual factors.Frontiers in sports and active living · 2025Article
- Effects of a six-month yoga intervention on vascular parameters in sedentary office workers: An interrupted time-series study design.Journal of education and health promotion · 2025Article
- Associations between cognitive function and vascular health in office-based sedentary workers: A six-month yoga intervention.Journal of education and health promotion · 2025Article
- Recovery pulse rate and cardiovascular function indices in young female adults following orthostasis.Journal of biological methods · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: High sedentary behaviour is associated with adverse effects on central vascular function and cognitive function. Although interventions to mitigate the adverse effects of workplace sitting are intriguing, evidence of the efficacy of such interventions remains lacking. This randomised cross-over trial was aimed at exploring the effectiveness of prolonged sitting, with or without physical activity breaks, on central, peripheral vascular and cognitive function in adults. Methods: Twenty one healthy adults completed 4 h of simulated work conditions in three experimental visits: (1) uninterrupted sitting (SIT); (2) sitting interrupted by 3 min of walking every hour (LIT); and (3) sitting interrupted by 3 min of stair climbing every hour (MIT). Carotid (CA) and superficial femoral artery (SFA) diameter, velocity, shear rate and blood flow were measured with Duplex ultrasound at 50 MHz at three time points (hours 0, 2 and 4), and executive function was assessed with the computer based Eriksen Flanker task every hour. Results: The decreases in reaction time (-30.59%) and accuracy (-10.56%) during SIT conditions were statistically significant, and less of a decrease was observed under LIT and MIT conditions. No significant differences in CA and SFA function were observed with LIT and MIT interventions. Conclusion: Physical activity breaks of varying intensity during prolonged sitting improve reaction time. However, the vascular benefits of physical activity breaks should be confirmed in the future through long term studies in natural environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.