Evidence map›Paper›PMID 36994173›Full record

ArticleSports medicine and health science2023

Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2.

Xinmeng Liu, Yang Yang, Heng Shao, Sujuan Liu, Yanmei Niu, Li Fu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sports medicine and health science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  11. Hot topics in muscle metabolism and adaptation.Sports medicine and health science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinmeng LiuDepartment of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Yang YangDepartment of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Heng ShaoDepartment of Anatomy and Histology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.
Sujuan LiuDepartment of Anatomy and Histology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.
Yanmei NiuDepartment of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Li FuDepartment of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Tianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin has been demonstrated to be a mediator of insulin sensitivity; however, the underlined mechanisms remain unclear. SESN2 is a stress-inducible protein that phosphorylates AMPK in different tissues. In this study, we aimed to validate the amelioration of insulin resistance by globular adiponectin (gAd) and to reveal the role of SESN2 in the improvement of glucose metabolism by gAd. We used a high-fat diet-induced wild-type and SESN2

Indexed as

AdiponectinAMP-Activated protein kinaseExercise trainingGlucose homeostasisSestrins

Identifiers

PMID36994173
PMCPMC10040333
OpenAlexW4293379490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.