Evidence map›Paper›PMID 36994115›Full record

ArticleJournal of Alzheimer's disease reports2023

Characterization of Depressive Symptoms in Dementia and Examination of Possible Risk Factors.

Lindsey I Sinclair, Michael A Lawton, Jennifer C Palmer, Alzheimer’s Disease Neuroimaging Initiative, Clive G Ballard

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindsey I SinclairDementia Research Group, Bristol Medical School, University of Bristol, Bristol, UK.
Michael A LawtonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Jennifer C PalmerPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Alzheimer’s Disease Neuroimaging Initiative
Clive G BallardMedical School, University of Exeter, Exeter, UK.

Funding

Medical Research Council MC_UU_00011/6Medical Research Council MR/T033371/1
6 · The paper itself

Abstract

Background: Depression in individuals with Alzheimer's disease (AD) is common, distressing, difficult to treat, and inadequately understood. It occurs more frequently in AD than in older adults without dementia. The reasons why some patients develop depression during AD and others do not remain obscure. Objective: We aimed to characterize depression in AD and to identify risk factors. Methods: We used data from three large dementia focused cohorts: ADNI ( Results: In individual studies there was no evidence of a difference in risk factors for depressive symptoms in AD. In the meta-analysis the only risk factor which increased the risk of depressive symptoms in AD was previous depression, but information on this was only available from one study (OR 7.78 95% CI 4.03-15.03). Conclusion: Risk factors for depression in AD appear to differ to those for depression per se supporting suggestions of a different pathological process, although a past history of depression was the strongest individual risk factor.

Indexed as

Alzheimer’s diseasedementiadepressiondepressive disorder

Identifiers

PMID36994115
PMCPMC10041449

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.