Evidence map›Paper›PMID 36993981›Full record

ArticleFrontiers in immunology2023

Alfred B Tiono, Nirianne Marie Q Palacpac, Edith Christiane Bougouma, Issa Nebie, Alphonse Ouédraogo, Sophie Houard, Nobuko Arisue, Flavia D'Alessio, Toshihiro Horii, Sodiomon B Sirima

Open access · goldFull text read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Alfred B TionoGroupe de Recherche Action en Santé, Ouagadougou (GRAS), Ouagadougou, Burkina Faso.
Nirianne Marie Q PalacpacDepartment of Malaria Vaccine Development, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Edith Christiane BougoumaGroupe de Recherche Action en Santé, Ouagadougou (GRAS), Ouagadougou, Burkina Faso.
Issa NebieGroupe de Recherche Action en Santé, Ouagadougou (GRAS), Ouagadougou, Burkina Faso.
Alphonse OuédraogoGroupe de Recherche Action en Santé, Ouagadougou (GRAS), Ouagadougou, Burkina Faso.
Sophie HouardEuropean Vaccine Initiative (EVI), Universitäts Klinikum Heidelberg, Heidelberg, Germany.
Nobuko ArisueDepartment of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Flavia D'AlessioEuropean Vaccine Initiative (EVI), Universitäts Klinikum Heidelberg, Heidelberg, Germany.
Toshihiro HoriiDepartment of Malaria Vaccine Development, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Sodiomon B SirimaGroupe de Recherche Action en Santé, Ouagadougou (GRAS), Ouagadougou, Burkina Faso.
Groupe de Recherche et d’Action sur le Foncier · BFThe University of Osaka · JPHeidelberg University · DECentre National de Recherche et de Formation sur le Paludisme · BF

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A vaccine targeting the erythrocyte stages of Methods: The primary trial was conducted to assess the safety and immunogenicity of the BK-SE36 in two cohorts of children aged 25-60 months (Cohort 1) and 12-24 months (Cohort 2). Immunization was at full dose (1.0 mL) administered at 0, 1, and 6 months. Blood samples were collected before each vaccination for immunological assessments and detection of Results: Of seventy-two (72) subjects that have received BK-SE36 vaccination, 71 had available blood smears during vaccination days. One month post Dose 2, the geometric mean of SE36 antibodies was 263.2 (95% CI: 178.9-387.1) in uninfected individuals compared to 77.1 (95% CI: 47.3-125.7) in infected participants. The same trend was observed one-month post booster dose. Participants uninfected at the time of booster vaccination had significantly higher GMTs compared to those who were infected (424.1 (95% CI: 301.9-595.8) Conclusion: Concomitant infection by Trial registration: WHO ICTRP, PACTR201411000934120.

Indexed as

MalariaMalaria, FalciparumMalaria VaccinesAntigens, ProtozoanChildHumansImmunityImmunoglobulin GPlasmodium falciparumVaccinationAntigens, ProtozoanImmunoglobulin GMalaria Vaccinesimmunogenicitymalaria blood-stage vaccinePlasmodium falciparumSE36SERA5serine repeat antigen

Identifiers

PMID36993981
PMCPMC10040972
OpenAlexW4324071981

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read39
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.