Evidence map›Paper›PMID 36993968›Full record

ArticleFrontiers in immunology2023

Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19

Larissa M G Cassiano, Vanessa Cavalcante-Silva, Marina S Oliveira, Bárbara V O Prado, Cristianne G Cardoso, Anna C M Salim, Gloria R Franco, Vânia D'Almeida, Saionara C Francisco, Roney S Coimbra

Open access · goldFull text read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Larissa M G CassianoNeurogenômica, Imunopatologia, Instituto René Rachou, Fiocruz, Belo Horizonte, Brazil.
Vanessa Cavalcante-SilvaDepartamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Marina S OliveiraNeurogenômica, Imunopatologia, Instituto René Rachou, Fiocruz, Belo Horizonte, Brazil.
Bárbara V O PradoHospital Metropolitano Dr. Célio de Castro, Belo Horizonte, Brazil.
Cristianne G CardosoHospital Metropolitano Dr. Célio de Castro, Belo Horizonte, Brazil.
Anna C M SalimPlataforma de Sequenciamento NGS (Next Generation Sequencing), Instituto René Rachou, Fiocruz, Belo Horizonte, Brazil.
Gloria R FrancoDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Vânia D'AlmeidaDepartamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Saionara C FranciscoHospital Metropolitano Dr. Célio de Castro, Belo Horizonte, Brazil.
Roney S CoimbraNeurogenômica, Imunopatologia, Instituto René Rachou, Fiocruz, Belo Horizonte, Brazil.
Hospital Felício Rocho · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genes

Indexed as

COVID-19DNA MethylationEpigenesis, GeneticInflammation MediatorsLeukocytesVitamin B 12AgedChemokine CCL3Down-RegulationFemaleHumansInflammationMaleMiddle AgedTranscriptomeChemokine CCL3Inflammation MediatorsVitamin B 12antiviral responsechromatin remodelingCOVID-19DNA methylationepidrugsepigenetic markingsinflammationvitamin B12

Identifiers

PMID36993968
PMCPMC10040807
OpenAlexW4324074117

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read22
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.