Evidence map›Paper›PMID 36993960›Full record

ArticleFrontiers in immunology2023

Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.

Changjie Yang, Qiwei Qian, Yudong Zhao, Bingyuan Huang, Ruilin Chen, Qiyu Gong, Hao Ji, Chenchen Wang, Lei Xia, Zhengrui You and 2 more

Open access · goldFull text read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. One Step Ahead: Preventing Tumor Adaptation to Immune Therapy.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2025
    Review
  8. Review
  9. Tumor-intrinsic PRMT5 upregulates FGL1Acta pharmaceutica Sinica. B · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy.Journal of clinical and translational hepatology · 2024
    Review
  17. New insights into T-cell exhaustion in liver cancer: from mechanism to therapy.Journal of cancer research and clinical oncology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Changjie YangDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Qiwei QianDivision of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yudong ZhaoDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Bingyuan HuangDivision of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Ruilin ChenDivision of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Qiyu GongShanghai Institute of Immunology, Shanghai Jiao Tong University, Shanghai, China.
Hao JiDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Chenchen WangDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Lei XiaDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhengrui YouDivision of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jianjun ZhangDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xiaosong ChenDepartment of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Renji Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: The key role of tissue-resident memory T (T Methods: The function and phenotype of intrahepatic CD8 Results: There was an increase in LAG3 expression in CD8 Conclusions: We identified CD8

Indexed as

Carcinoma, HepatocellularFibrinogenLiver NeoplasmsT-Cell ExhaustionAnimalsCD8-Positive T-LymphocytesHumansMiceTumor MicroenvironmentFGL1 protein, humanFibrinogenexhaustiongranzyme Bhepatocellular carcinomalymphocyte activation gene 3tissue-resident memory T cells

Identifiers

PMID36993960
PMCPMC10040674
OpenAlexW4324087819

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read13
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.