Evidence map›Paper›PMID 36993946›Full record

ArticleBrain communications2023

B lymphocyte responses in Parkinson's disease and their possible significance in disease progression.

Kirsten M Scott, Yen Ting Chong, Seoyoung Park, Ruwani S Wijeyekoon, Shaista Hayat, Rebeccah J Mathews, Zachary Fitzpatrick, Pam Tyers, Georgia Wright, Jennifer Whitby and 4 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  11. Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Kirsten M ScottJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.ORCID https://orcid.org/0000-0003-3121-5963
Yen Ting ChongJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Seoyoung ParkJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Ruwani S WijeyekoonJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Shaista HayatJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Rebeccah J MathewsMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.
Zachary FitzpatrickMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.
Pam TyersJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Georgia WrightUniversity of Cambridge Clinical School of Medicine, Cambridge CB2 OQQ, UK.
Jennifer WhitbyUniversity of Cambridge Clinical School of Medicine, Cambridge CB2 OQQ, UK.
Roger A BarkerJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Michele T HuDivision of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Caroline H Williams-GrayJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.
University of Cambridge · GBJohn Radcliffe Hospital · GB

Funding

Medical Research Council MR/R007446/1Medical Research Council MR/W029235/1Wellcome Trust
6 · The paper itself

Abstract

Inflammation contributes to Parkinson's disease pathogenesis. We hypothesized that B lymphocytes are involved in Parkinson's disease progression. We measured antibodies to alpha-synuclein and tau in serum from patients with rapid eye movement sleep behaviour disorder (

Indexed as

alpha-synuclein antibodiesB lymphocytesParkinson’s diseaseregulatory B cells

Identifiers

PMID36993946
PMCPMC10042276
OpenAlexW4323656815

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read43
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.