ArticleHeart rhythm O22023
Prolonged PR interval and incidence of atrial fibrillation, heart failure admissions, and mortality in patients with implanted cardiac devices: A real-world survey.
Article in Heart rhythm O2, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Empowering atrial fibrillation detection with TabPFN and SHAP interpretation based on ECG-derived features: a dual-center temporal validation study.BMC cardiovascular disorders · 2026Article
- The Prognostic Ability of ECG Findings in Predicting Cardiovascular Events: A Five-Year Nested Case-Cohort Study in an Iranian Population (Shiraz Heart Study).Health science reports · 2026Article
- Cisd2 delays atrial aging via a modulation of calcium homeostasis that mitigates atrial myopathy.Cell communication and signaling : CCS · 2025Article
- Association of electrocardiogram features with risk of obstructed sleep apnea: a population-based cohort study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Vascular function assessed by flow-mediated vasodilation and nitroglycerine-induced vasodilation in subjects with first-degree atrioventricular block.Scientific reports · 2024Article
- Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort.Environmental health : a global access science source · 2024Article
- Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort.Research square · 2024Article
- Can prolonged P-R interval predict clinical outcomes in non-ST elevation acute coronary syndrome patients?BMC cardiovascular disorders · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prolongation of the PR interval has long been considered a benign condition, particularly in the setting of nonstructural heart disease. Objective: The purpose of this study was to investigate the effect of PR interval on various well-adjudicated cardiovascular outcomes using a large real-world population data of patients with implanted dual-chamber permanent pacemakers or implantable cardioverter-defibrillators. Methods: PR intervals were measured during remote transmissions in patients with implanted permanent pacemakers or implantable cardioverter-defibrillators. Study endpoints (time to the first occurrence of AF, heart failure hospitalization [HFH], or death) were obtained between January 2007 and June 2019 from the deidentified Optum de-identified Electronic Health Record dataset. Results: A total of 25,752 patients (age 69.3 ± 13.9 years; 58% male) were evaluated. The average intrinsic PR interval was 185 ± 55 ms. In the subset of 16,730 patients with available long-term device diagnostic data, a total of 2555 (15.3%) individuals developed AF during 2.59 ± 2.18 years of follow-up. The incidence of AF was significantly higher (up to 30%) in patients with a longer PR interval (ie, PR interval ≥270 ms; Conclusion: In a large real-world population of patients with implanted devices, PR interval prolongation was significantly associated with increased incidence of AF, HFH, or death.
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