SynthesisFrontiers in aging neuroscience2023
Association of thyroid disease with risks of dementia and cognitive impairment: A meta-analysis and systematic review.
Synthesis in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association of overt hypothyroidism with risks of cognitive impairment: a meta-analysis and systematic review.Frontiers in endocrinology · 2025Pooled it
- Gut microbiota of patients with post-stroke depression in Chinese population: a systematic review and meta-analysis.Frontiers in cellular and infection microbiology · 2025Pooled it
- The Association of Thyroid Disease with Risk of Dementia and Cognitive Impairment: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Subclinical hyperthyroidism and the risk of dementia: A meta-analysis.Brain and behavior · 2024Pooled it
- Association of hypoglycaemia with the risks of arrhythmia and mortality in individuals with diabetes - a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution-Based Cross-Sectional Study.Health science reports · 2026Article
- Right-lateralized maladaptive topological reorganization in hyperthyroidism.Journal of neuroendocrinology · 2026Article
- Beyond Hormone Levels: Thyroid Hormone Signaling from Neurogenesis to Alzheimer's Disease.Cells · 2026Review
- Impact of hypothyroidism and hyperthyroidism on endometrial cancer incidence: results from a large population-based cohort study.European journal of epidemiology · 2026Article
- The type 2 deiodinase Thr92Ala polymorphism and cognitive aging: current evidence and biological context.Therapeutic advances in endocrinology and metabolism · 2026Review
- Independent and combined associations of diabetes and thyroid disorders with risks of incident dementia.Frontiers in endocrinology · 2026Article
- Neurological consequences of adult-onset hypothyroidism.Endocrine journal · 2025Review
- Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale.Science advances · 2025Article
- Genetic evidence suggests a causal relationship linking thyroid function to prospective memory and dementia and Parkinson's disease.Scientific reports · 2025Article
- The impact of autoimmune thyroid disease on cognitive and psychiatric disorders: focus on clinical, pre-clinical and molecular studies.European thyroid journal · 2025Review
- Urinary selenium, cranial MRI, and cognitive function in American Indians: The Strong Heart Study.Environmental research · 2025Article
- Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data.Alzheimer's research & therapy · 2024Article
- Graves disease is associated with increased risk of clinical Alzheimer's disease: evidence from the Medicare system.Clinical diabetes and endocrinology · 2024Article
- Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.Frontiers in medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: It is still uncertain whether the risk of dementia and cognitive impairment is related to thyroid disease. we carried out a meta-analysis and systematic review (PROSPERO: CRD42021290105) on the associations between thyroid disease and the risks of dementia and cognitive impairment. Methods: We searched PubMed, Embase, and Cochrane Library for studies published up to August 2022. The overall relative risk (RRs) and its 95% confidence interval (CIs) were calculated in the random-effects models. Subgroup analyses and meta-regression were conducted to explore the potential source of heterogeneity among studies. We tested and corrected for publication bias by funnel plot-based methods. The Newcastle-Ottawa Scale (NOS) or Agency for Healthcare Research and Quality (AHRQ) scale were used to evaluate the study quality of longitudinal studies and cross-sectional studies, respectively. Results: A total of 15 studies were included in our meta-analysis. Our meta-analysis showed that hyperthyroidism (RR = 1.14, 95% CI = 1.09-1.19) and subclinical hyperthyroidism (RR = 1.56, 95% CI = 1.26-1.93) might be associated with an elevated risk for dementia, while hypothyroidism (RR = 0.93, 95% CI = 0.80-1.08) and subclinical hypothyroidism (RR = 0.84, 95% CI = 0.70-1.01) did not affect the risk. Discussion: Hyperthyroidism and subclinical hyperthyroidism are predictors of dementia. Systematic review registration: PROSPERO, Identifier: CRD42021290105.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.