Evidence map›Paper›PMID 36993868›Full record

ArticleNature aging2023

Shared and disease-specific glial gene expression changes in neurodegenerative diseases.

Abstract readComment
In one paragraph

Article in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Glial Cells in Behavioral and Psychological Symptoms of Alzheimer's Disease.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

0 authors.

Funding

Dissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysisR01NS123571 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2025
$3.6M
Optimization of imaging mass cytometry, a single-cell spatial proteomics technology, for the study of Alzheimer diseaseR21AG077643 · NIA · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2022 to 2022
$433k
Define molecular events driving selective neuronal death in multiple neurodegenerative diseases by snRNA-seqR03AG070474 · NIA · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2022
$315k
NIA NIH HHS R03 AG070474NIA NIH HHS R21 AG077643NINDS NIH HHS R01 NS123571
6 · The paper itself

Abstract

We found evolutionarily conserved astrocyte and microglia subpopulations shared across multiple brain regions. We reveal similarities and differences between Alzheimer's disease glia and Parkinson's disease glia, as well as regional variance linked to disease pathology and neurodegeneration.

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesGene ExpressionHumansMicrogliaNeuroglia

Identifiers

PMID36993868
PMCPMC10046492

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.