Evidence map›Paper›PMID 36993756›Full record

ArticlebioRxiv : the preprint server for biology2023

GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancers.

Anuja Sathe, Carlos Ayala, Xiangqi Bai, Susan M Grimes, Byrne Lee, Cindy Kin, Andrew Shelton, George Poultsides, Hanlee P Ji

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anuja SatheDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Carlos AyalaDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA, United States.
Xiangqi BaiDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Susan M GrimesDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Byrne LeeDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA, United States.
Cindy KinDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA, United States.
Andrew SheltonDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA, United States.
George PoultsidesDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA, United States.
Hanlee P JiDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Stanford University · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Systematic discovery of neomorph protein-protein interactions in cancer for oncogenic pathway perturbationU01CA217875 · NCI · EMORY UNIVERSITY · PI FU, HAIAN · 2017 to 2021
$4.5M
Omics information maximization in single-cell sequencing with hybrid molecular and computational approachesR35HG011292 · NHGRI · STANFORD UNIVERSITY · PI LAU, BILLY TSZ CHEONG · 2020 to 2024
$2.3M
Multimodal iterative sequencing of cancer genomes and single tumor cellsR33CA247700 · NCI · STANFORD UNIVERSITY · PI JI, HANLEE P · 2021 to 2023
$1.1M
NCI NIH HHS P30 CA124435NCI NIH HHS R33 CA247700NCI NIH HHS U01 CA217875NHGRI NIH HHS R35 HG011292
6 · The paper itself

Abstract

Understanding the cellular mechanisms of novel immunotherapy agents in the human tumor microenvironment (

Indexed as

colon cancergastric cancerGITRscRNA-seqTIGITtumor microenvironment

Identifiers

PMID36993756
PMCPMC10054933
OpenAlexW4324348873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.