Evidence map›Paper›PMID 36993738›Full record

ArticlebioRxiv : the preprint server for biology2023

Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2.

Yang Suo, Nicholas J Wright, Hugo Guterres, Justin G Fedor, Kevin John Butay, Mario J Borgnia, Wonpil Im, Seok-Yong Lee

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yang SuoDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Nicholas J WrightDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Hugo GuterresDepartments of Biological Sciences, Chemistry, and Bioengineering, Lehigh University, Bethlehem, Pennsylvania, 18015, USA.
Justin G FedorDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Kevin John ButayGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Mario J BorgniaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Wonpil ImDepartments of Biological Sciences, Chemistry, and Bioengineering, Lehigh University, Bethlehem, Pennsylvania, 18015, USA.
Seok-Yong LeeDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Duke University · USLehigh University · USNational Institutes of Health · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
NIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0M
Molecular basis of adenosine transport and reuptake inhibition in humanR01GM137421 · NIGMS · DUKE UNIVERSITY · PI HONG, JIYONG, LEE, SEOK-YONG · 2020 to 2023
$1.7M
CHARMM-GUI Development for Biomolecular Modeling and Simulation CommunityR01GM138472 · NIGMS · LEHIGH UNIVERSITY · PI IM, WONPIL · 2020 to 2023
$1.5M
Intramural NIH HHS ZIC ES103326NCI NIH HHS P30 CA016086NIGMS NIH HHS R01 GM137421NIGMS NIH HHS R01 GM138472
6 · The paper itself

Abstract

A wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition

Identifiers

PMID36993738
PMCPMC10055046
OpenAlexW4327757708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.