Evidence map›Paper›PMID 36993718›Full record

ArticlebioRxiv : the preprint server for biology2025

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer.

Alvaro Curiel-Garcia, Sam R Holmstrom, Cristina Castillo, Carmine F Palermo, Steven A Sastra, Anthony Andren, Lorenzo Tomassoni, Li Zhang, Tessa Y S Le Large, Irina Sagalovskiy and 16 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 6 institutions in 3 countries.

Alvaro Curiel-GarciaHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0001-6249-3267
Sam R HolmstromDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Cristina CastilloDepartment of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.
Carmine F PalermoHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.
Steven A SastraHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.
Anthony AndrenDepartment of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.
Lorenzo TomassoniHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.
Li ZhangDepartment of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.
Tessa Y S Le LargeDepartment of Surgery, Amsterdam UMC, Location Vrije Unversiteit, Amsterdam, Netherlands.
Irina SagalovskiyHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-9107-6283
Daniel R RossHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.
Winston WongHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.
Kaitlin ShawDivision of GI/Endocrine Surgery, Department of Surgery, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.ORCID 0000-0002-6464-8290
Jeanine GenkingerDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.ORCID 0000-0002-8438-0412
Hanina HibshooshDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
Gulam A ManjiHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0001-9817-2414
Alina C IugaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-2351-8289
Roland M SchmidDepartment of Internal Medicine II, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.ORCID 0000-0002-5751-7313
Kristen JohnsonUniversity of New Hampshire, Manchester, NH.
Michael A BadgleyHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-2745-696X
Pasquale LaiseHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.
Costas A LyssiotisDepartment of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.ORCID 0000-0001-9309-6141
Yatrik M ShahDepartment of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.
Andrea CalifanoHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0003-4742-3679
H Carlo MaurerHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-2193-6014
Kenneth P OliveHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-3392-8994
Columbia University Irving Medical Center · USUniversity of Michigan · USUniversity of New Hampshire at Manchester · USColumbia University · USDutch Cancer Society · NLUniversity of North Carolina at Chapel Hill · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Ultrastructural analysis of axonal Kv2-mediated endoplasmic reticulum/plasma membrane (ER/PM) junctionsP20GM103506 · NIGMS · DARTMOUTH COLLEGE · PI STEVEN FIERING · 2012 to 2026
$60.1M
Predicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell LevelR35CA197745 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDREA CALIFANO · 2015 to 2026
$11.5M
The Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2M
Elucidation and targeting of paracrine cascades in PDACU01CA274312 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gulam Abbas Manji, Kenneth P. Olive · 2022 to 2026
$4.9M
Targeting cysteine import to induce ferroptotic cell death in pancreatic cancerR01CA215607 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Kenneth P. Olive · 2017 to 2026
$4.0M
High Performance Computing Cluster for Biomedical ResearchS10OD032433 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2023 to 2023
$2.0M
Targeting metabolic stress to induce pancreatic tumor cell deathR01CA244931 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$1.9M
NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA215607NCI NIH HHS R01 CA244931NCI NIH HHS R35 CA197745NCI NIH HHS U01 CA274312NIDDK NIH HHS P30 DK132710NIGMS NIH HHS P20 GM103506NIH HHS S10 OD032433
6 · The paper itself

Abstract

KRAS is the archetypal oncogenic driver of pancreatic cancer. To identify new modulators of KRAS activity in human pancreatic ductal adenocarcinoma (PDAC), we performed regulatory network analysis on a large collection of expression profiles from laser capture microdissected samples of PDAC and benign controls. We discovered that BMAL2, a member of the PAS family of transcription factors, promotes tumor initiation, progression, and post-resection survival, and is highly correlated with KRAS activity. Functional analysis of BMAL2 target genes suggested a role in regulating the hypoxia response, a hallmark of PDAC. Knockout of

Identifiers

PMID36993718
PMCPMC10055246
OpenAlexW4328132512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.