Evidence map›Paper›PMID 36993688›Full record

ArticlebioRxiv : the preprint server for biology2023

Quantification of elongation stalls and impact on gene expression in yeast.

Wanfu Hou, Vince Harjono, Alex T Harvey, Arvind Rasi Subramaniam, Brian M Zid

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wanfu HouDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Vince HarjonoDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Alex T HarveyDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Arvind Rasi SubramaniamBasic Sciences Division and Computational Biology Section of Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Brian M ZidDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
University of California San Diego · USFred Hutch Cancer Center · US

Funding

Undergraduate Summer Research Supplement to R35R35GM128798 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZID, BRIAN MATTHEW · 2018 to 2023
$2.3M
NIGMS NIH HHS R35 GM128798
6 · The paper itself

Abstract

Ribosomal pauses are a critical part of co-translational events including protein folding and localization. However, extended ribosome pauses can lead to ribosome collisions, resulting in the activation of ribosome rescue pathways and turnover of protein and mRNA. While this relationship has been known, the specific threshold between permissible pausing versus activation of rescue pathways has not been quantified. We have taken a method used to measure elongation time and adapted it for use in

Identifiers

PMID36993688
PMCPMC10055187
OpenAlexW4328114229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.