Evidence map›Paper›PMID 36993650›Full record

ArticlebioRxiv : the preprint server for biology2023

General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.

Joanna E Moodie, Sarah E Harris, Mathew A Harris, Colin R Buchanan, Gail Davies, Adele Taylor, Paul Redmond, David Liewald, Maria Del C Valdés Hernández, Susan Shenkin and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Joanna E MoodieLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Mathew A HarrisLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Colin R BuchananLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Gail DaviesLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Adele TaylorLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Paul RedmondLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
David LiewaldLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Maria Del C Valdés HernándezLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Susan ShenkinLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Tom C RussLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Susana Muñoz ManiegaLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Michelle LucianoLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Janie CorleyLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Aleks StolicynDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK.
Xueyi ShenDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK.
Douglas SteeleScottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK.
Gordon WaiterScottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK.
Anca Sandu-GiuraniucScottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK.
Mark E BastinLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Joanna M WardlawLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Andrew McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK.
Heather WhalleyDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK.
Elliot M Tucker-DrobDepartment of Psychology, University of Texas, Austin, Texas 78712-0187, USA.
Ian J DearyLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.
Simon R CoxLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, UK.

Funding

Evaluating Longitudinal Changes in the Human Structural Connectome in Relation to Cognitive AgingR01AG054628 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2017 to 2021
$2.7M
Medical Research Council MR/K026992/1Medical Research Council MR/M013111/1Medical Research Council MR/R024065/1NIA NIH HHS R01 AG054628Wellcome Trust
6 · The paper itself

Abstract

Gene expression varies across the brain. This spatial patterning denotes specialised support for particular brain functions. However, the way that a given gene's expression fluctuates across the brain may be governed by general rules. Quantifying patterns of spatial covariation across genes would offer insights into the molecular characteristics of brain areas supporting, for example, complex cognitive functions. Here, we use principal component analysis to separate general and unique gene regulatory associations with cortical substrates of cognition. We find that the region-to-region variation in cortical expression profiles of 8235 genes covaries across two major principal components : gene ontology analysis suggests these dimensions are characterised by downregulation and upregulation of cell-signalling/modification and transcription factors. We validate these patterns out-of-sample and across different data processing choices. Brain regions more strongly implicated in general cognitive functioning (

Identifiers

PMID36993650
PMCPMC10055068

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.