Evidence map›Paper›PMID 36993638›Full record

ArticlebioRxiv : the preprint server for biology2023

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function.

Paul Renauer, Jonathan J Park, Meizhu Bai, Arianny Acosta, Won-Ho Lee, Guang Han Lin, Yueqi Zhang, Xiaoyun Dai, Guangchuan Wang, Youssef Errami and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Paul RenauerDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Jonathan J ParkDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Meizhu BaiDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Arianny AcostaDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Won-Ho LeeDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Guang Han LinDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Yueqi ZhangDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Xiaoyun DaiDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Guangchuan WangDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Youssef ErramiDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Terence WuWest Campus Analytical Core, Mass Spectrometry/Proteomics Facility, West Haven, Connecticut, USA.
Paul ClarkDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Lupeng YeDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Quanjun YangDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Sidi ChenDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Yale Cancer Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
(PQ4) Novel tools for in vivo study of genetic interactions in cancer progressionR01CA231112 · NCI · YALE UNIVERSITY · PI CHEN, SIDI · 2018 to 2022
$3.0M
High-throughput in vivo genetics for immunotherapy target discoveryDP2CA238295 · NCI · YALE UNIVERSITY · PI CHEN, SIDI · 2018 to 2018
$2.5M
New approaches for single cell tagging, editing and profiling of glial cells in vivoRF1DA048811 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HONG, WEIZHE · 2019 to 2019
$2.4M
Rapidly scalable platforms for direct in vivo screening of functional drivers in lethal cancersR33CA225498 · NCI · YALE UNIVERSITY · PI CHEN, SIDI · 2019 to 2021
$1.2M
NCI NIH HHS DP2 CA238295NCI NIH HHS R01 CA231112NCI NIH HHS R33 CA225498NIDA NIH HHS RF1 DA048811NIGMS NIH HHS T32 GM007205NIGMS NIH HHS T32 GM007499
6 · The paper itself

Abstract

Immune evasion is a critical step of cancer progression that remains a major obstacle for current T cell-based immunotherapies. Hence, we seek to genetically reprogram T cells to exploit a common tumor-intrinsic evasion mechanism, whereby cancer cells suppress T cell function by generating a metabolically unfavorable tumor microenvironment (TME). Specifically, we use an Synopsis: The authors identify the adenosine deaminase gene (ADA) as a regulatory gene that reprograms T cell metabolism. ADA-overexpression (OE) in α-CD19 and α-HER2 CAR-T cells increases proliferation, cytotoxicity, memory, and decreases exhaustion, and ADA-OE α-HER2 CAR-T cells have enhanced clearance of HT29 human colorectal cancer tumors

Identifiers

PMID36993638
PMCPMC10055032
OpenAlexW4324386086

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.