Evidence map›Paper›PMID 36993600›Full record

ArticleResearch square2023

Mediating role of obesity on the association between disadvantaged neighborhoods and intracortical myelination.

Lisa Kilpatrick, Keying Zhang, Tien Dong, Gilbert Gee, Hiram Beltran-Sanchez, May Wang, Jennifer Labus, Bruce Naliboff, Emeran Mayer, Arpana Gupta

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Lisa KilpatrickUniversity of California Los Angeles.
Keying ZhangUniversity of California Los Angeles.
Tien DongUniversity of California Los Angeles.ORCID 0000-0003-0105-8063
Gilbert GeeUniversity of California Los Angeles.
Hiram Beltran-SanchezUniversity of California Los Angeles.
May WangUniversity of California Los Angeles.ORCID 0000-0002-8682-9789
Jennifer LabusUniversity of California Los Angeles.
Bruce NaliboffUniversity of California Los Angeles.
Emeran MayerUniversity of California Los Angeles.
Arpana GuptaUniversity of California Los Angeles.ORCID 0000-0002-1669-9624

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HIRAM BELTRAN-SANCHEZ · 2016 to 2026
$6.9M
Social Isolation and Discrimination as Stressors Influencing Brain-Gut Microbiome Alterations among Filipino and Mexican AmericanR01MD015904 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2021 to 2025
$4.1M
Role of Inflammatory Processes in Reward Network Alterations in ObesityK23DK106528 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2016 to 2020
$1.0M
Role of the Gut Microbiome in Reward Network Alterations in ObesityR03DK121025 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2020 to 2021
$234k
NCATS NIH HHS UL1 TR001881NICHD NIH HHS P2C HD041022NIDDK NIH HHS K23 DK106528NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK048351NIDDK NIH HHS R03 DK121025NIDDK NIH HHS T32 DK007180NIMHD NIH HHS R01 MD015904
6 · The paper itself

Abstract

We investigated the relationship between neighborhood disadvantage (area deprivation index [ADI]) and intracortical myelination (T1-weighted/T2-weighted ratio at deep to superficial cortical levels), and the potential mediating role of the body mass index (BMI) and perceived stress in 92 adults. Worse ADI was correlated with increased BMI and perceived stress (p's<.05). Non-rotated partial least squares analysis revealed associations between worse ADI and decreased myelination in middle/deep cortex in supramarginal, temporal, and primary motor regions and increased myelination in superficial cortex in medial prefrontal and cingulate regions (p<.001); thus, neighborhood disadvantage may influence the flexibility of information processing involved in reward, emotion regulation, and cognition. Structural equation modelling revealed increased BMI as partially mediating the relationship between worse ADI and observed myelination increases (p=.02). Further, trans-fatty acid intake was correlated with observed myelination increases (p=.03), suggesting the importance of dietary quality. These data further suggest ramifications of neighborhood disadvantage on brain health.

Identifiers

PMID36993600
PMCPMC10055549

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.