Evidence map›Paper›PMID 36993599›Full record

ArticlebioRxiv : the preprint server for biology2023

Transposon-encoded nucleases use guide RNAs to selfishly bias their inheritance.

Chance Meers, Hoang Le, Sanjana R Pesari, Florian T Hoffmann, Matt W G Walker, Jeanine Gezelle, Samuel H Sternberg

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chance MeersDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.
Hoang LeDepartment of Biology, University of Pennsylvania, Philadelphia, PA.
Sanjana R PesariDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.
Florian T HoffmannDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.
Matt W G WalkerDepartment of Biological Sciences, Columbia University, New York, NY.
Jeanine GezelleDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.
Columbia University · USUniversity of Pennsylvania · US

Funding

Uncovering the molecular function of novel transposon-encoded Cas9 homologsF32GM143924 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MEERS, CHANCE · 2022 to 2023
$139k
NIGMS NIH HHS F32 GM143924
6 · The paper itself

Abstract

Insertion sequences (IS) are compact and pervasive transposable elements found in bacteria, which encode only the genes necessary for their mobilization and maintenance. IS

Identifiers

PMID36993599
PMCPMC10055086
OpenAlexW4324377422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.