ArticlebioRxiv : the preprint server for biology2023
Bacterial genome engineering using CRISPR RNA-guided transposases.
Diego R Gelsinger, Phuc Leo H Vo, Sanne E Klompe, Carlotta Ronda, Harris Wang, Samuel H Sternberg
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors at 2 institutions in 1 country.
Diego R GelsingerDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Phuc Leo H VoDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA.
Sanne E KlompeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Carlotta RondaDepartment of Systems Biology, Columbia University, New York, NY, USA.
Harris WangDepartment of Systems Biology, Columbia University, New York, NY, USA.
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Columbia University · USVertex Pharmaceuticals (United States) · US
Funding
Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human DiseaseRM1HG009490 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Brittany S. Adamson, Martin Joseph Ankrah Aryee · 2017 to 2026
$22.7MMicron-scale Spatial Metagenomic Mapping of Microbial Biogeography in the Gastrointestinal TractR01AI132403 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Harris H Wang · 2017 to 2026
$6.0MEcological dynamics and metabolic interactions in thegut microbiome across space and timeR01DK118044 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VITKUP, DENNIS, WANG, HARRIS H · 2018 to 2022
$3.4MA high-performance and versatile technology for precision microbiome engineeringR01EB031935 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Samuel Henry Sternberg, Harris H Wang · 2021 to 2026
$3.3MLeveraging Programmable Integrases for Human Genome EngineeringDP2HG011650 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERNBERG, SAMUEL HENRY · 2020 to 2020
$2.4MImpact of CRISPR-associated transposons on anti-phage immunity in Vibrio choleraeR21AI168976 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERNBERG, SAMUEL HENRY · 2022 to 2023
$446kNHGRI NIH HHS DP2 HG011650NHGRI NIH HHS RM1 HG009490NIAID NIH HHS R01 AI132403NIAID NIH HHS R21 AI168976NIBIB NIH HHS R01 EB031935NIDDK NIH HHS R01 DK118044
6 · The paper itselfAbstract
CRISPR-associated transposons (CASTs) have the potential to transform the technology landscape for kilobase-scale genome engineering, by virtue of their ability to integrate large genetic payloads with high accuracy, easy programmability, and no requirement for homologous recombination machinery. These transposons encode efficient, CRISPR RNA-guided transposases that execute genomic insertions in
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PMID36993567
PMCPMC10055292
OpenAlexW4328052609
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