ArticlebioRxiv : the preprint server for biology2023
Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance.
Jessica M Phan, Benjamin C Creekmore, Aivi T Nguyen, Darya D Bershadskaya, Nabil F Darwich, Edward B Lee
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 9 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors at 1 institution in 1 country.
Jessica M PhanTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Benjamin C CreekmoreTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Aivi T NguyenTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Darya D BershadskayaTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Nabil F DarwichTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Edward B LeeTranslational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
University of Pennsylvania · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0MResearch Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8MUnderstanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Edward Byung-Ha Lee · 2020 to 2026
$18.8MTraining in Alzheimer’s and Age-Related Neurodegenerative DiseasesT32AG000255 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN, VIRGINIA M LEE · 1997 to 2026
$12.5MLoss of VCP Function in Frontotemporal Lobar DegenerationRF1AG065341 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, EDWARD BYUNG-HA · 2022 to 2022
$2.4MMechanism of VCP interaction and processing of neurodegenerative tau fibrilsF30AG077756 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CREEKMORE, BENJAMIN · 2022 to 2024
$88kNIA NIH HHS F30 AG077756NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG072979NIA NIH HHS RF1 AG065341NIA NIH HHS T32 AG000255NIGMS NIH HHS T32 GM007170
6 · The paper itselfAbstract
Identifiers
PMID36993559
PMCPMC10055171
OpenAlexW4327612709
What OpenQuestion holds
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LicenceCC BY-NC-ND
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