Evidence map›Paper›PMID 36993554›Full record

ArticlebioRxiv : the preprint server for biology2023

Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism.

Daniel Levy, Sanaz Nourmohammadi Abadchi, Niloufar Shababi, Mohsen Rouhani Ravari, Nicholas H Pirolli, Cade Bergeron, Angel Obiorah, Farzad Mokhtari-Esbuie, Shayan Gheshlaghi, John M Abraham and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Daniel LevyFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Sanaz Nourmohammadi AbadchiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Niloufar ShababiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Mohsen Rouhani RavariDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Nicholas H PirolliFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Cade BergeronFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Angel ObiorahFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Farzad Mokhtari-EsbuieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Shayan GheshlaghiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
John M AbrahamDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Ian M SmithFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Emily PowsnerFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Talia SolomonFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
John W HarmonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Steven M JayFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
University of Maryland, College Park · USJohns Hopkins University · US

Funding

Vascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7M
Characterization of the Cardiac Progenitor Cell Exosomes for Optimal TherapeuticsR01HL141922 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAUSHAL, SUNJAY · 2019 to 2022
$2.8M
Dementia Following Spinal Cord Injury: Mechanism and Therapeutic TargetingRF1NS110637 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JAY, STEVEN MICHAEL, WU, JUNFANG · 2019 to 2019
$2.8M
Controlling Exosome Noncoding RNA Cargo for Enhanced Wound HealingR01HL141611 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI JAY, STEVEN MICHAEL · 2018 to 2022
$1.9M
Enabling exosome biomarker development via digitized single vesicle analysisR01GM130923 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, WHITE, IAN M · 2019 to 2022
$1.7M
Nanohydrocyclones for scalable extracellular vesicle purification and drug loadingR21HL159590 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI DEVOE, DON L, JAY, STEVEN MICHAEL · 2021 to 2022
$421k
NHLBI NIH HHS R01 HL141611NHLBI NIH HHS R01 HL141922NHLBI NIH HHS R21 HL159590NHLBI NIH HHS T32 HL007698NIGMS NIH HHS R01 GM130923NINDS NIH HHS RF1 NS110637
6 · The paper itself

Abstract

Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) have recently been widely explored in clinical trials for treatment of diseases with complex pathophysiology. However, production of MSC EVs is currently hampered by donor-specific characteristics and limited

Identifiers

PMID36993554
PMCPMC10055496
OpenAlexW4360610710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.