Evidence map›Paper›PMID 36993548›Full record

ArticlebioRxiv : the preprint server for biology2023

ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions.

Xin Huang, Sophie Balmer, Cong Lyu, Yunlong Xiang, Vikas Malik, Hailin Wang, Yu Zhang, Wei Xie, Anna-Katerina Hadjantonakis, Hongwei Zhou and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Xin HuangDepartment of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sophie BalmerDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cong LyuResearch Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Yunlong XiangTsinghua Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Vikas MalikDepartment of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Hailin WangResearch Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Yu ZhangTsinghua Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Wei XieTsinghua Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Anna-Katerina HadjantonakisDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Hongwei ZhouDepartment of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Jianlong WangDepartment of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Columbia University Irving Medical Center · USCenter for Life Sciences · CNChinese Academy of Sciences · CNMemorial Sloan Kettering Cancer Center · USObstetrics and Gynecology Hospital of Fudan University · CN

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Mechanisms driving cell fate specification and morphogenesis in the blastocystR01HD094868 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI ANNA-KATERINA HADJANTONAKIS · 2018 to 2026
$4.2M
The gut endoderm: origin, formation and fateR01DK127821 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI ANNA-KATERINA HADJANTONAKIS · 2021 to 2026
$3.4M
RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cellsR01HD095938 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, JIANLONG · 2018 to 2022
$1.7M
Defining Novel Molecular Pathways to TotipotencyR01HD097268 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, JIANLONG · 2018 to 2022
$1.7M
TET2-mediated transcriptional and epigenetic control of normal and malignant hematopoiesisR01HL146664 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WANG, JIANLONG, XU, MINGJIANG · 2019 to 2022
$1.7M
Transcriptional and Epigenetic Control of Pluripotency and Development by Zfp281R01GM129157 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, JIANLONG · 2018 to 2021
$1.3M
SINE-mediated Regulation of mRNA Epitranscriptome for Pluripotency Maintenance and DifferentiationR21HD106263 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUANG, XIN · 2022 to 2023
$452k
NCI NIH HHS P30 CA008748NHLBI NIH HHS R01 HL146664NICHD NIH HHS R01 HD094868NICHD NIH HHS R01 HD095938NICHD NIH HHS R01 HD097268NICHD NIH HHS R21 HD106263NIDDK NIH HHS R01 DK127821NIGMS NIH HHS R01 GM129157
6 · The paper itself

Abstract

The progression from naive through formative to primed

Indexed as

DNA methylationDNMT3formativenaivePluripotencyprimedR-loopTET1ZFP281

Identifiers

PMID36993548
PMCPMC10055359
OpenAlexW4360944175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.