ArticlebioRxiv : the preprint server for biology2023
RTF2 controls replication repriming and ribonucleotide excision at the replisome.
Brooke A Conti, Penelope D Ruiz, Cayla Broton, Nicolas J Blobel, Molly C Kottemann, Sunandini Sridhar, Francis P Lach, Tom Wiley, Nanda K Sasi, Thomas Carroll and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 1 institution in 1 country.
Brooke A ContiLaboratory of Genome Maintenance, The Rockefeller University.
Penelope D RuizLaboratory of Genome Maintenance, The Rockefeller University.
Cayla BrotonLaboratory of Genome Maintenance, The Rockefeller University.
Nicolas J BlobelLaboratory of Genome Maintenance, The Rockefeller University.
Molly C KottemannLaboratory of Genome Maintenance, The Rockefeller University.
Sunandini SridharLaboratory of Genome Maintenance, The Rockefeller University.
Francis P LachLaboratory of Genome Maintenance, The Rockefeller University.
Tom WileyLaboratory of Genome Maintenance, The Rockefeller University.
Nanda K SasiLaboratory for Cell Biology and Genetics, The Rockefeller University.
Thomas CarrollBioinformatics, The Rockefeller University.
Agata SmogorzewskaLaboratory of Genome Maintenance, The Rockefeller University.
Rockefeller University · US
Funding
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MGenetics and Cell BiologyT32GM066699 · NIGMS · ROCKEFELLER UNIVERSITY · PI STRICKLAND, SIDNEY · 2004 to 2021
$7.6MUnderstanding Replication Stress Response in Mammalian CellsR01GM140400 · NIGMS · ROCKEFELLER UNIVERSITY · PI SMOGORZEWSKA, AGATA · 2021 to 2024
$1.4MMechanisms of genomic instability, tumor initiation and progression following the disruption of the RTF2-RNase H2 axisF30CA268717 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLOBEL, NICOLAS JOHANNES · 2022 to 2025
$213kUnderstanding the regulatory mechanisms for Replication Termination Factor 2 (RTF2) removal and function during DNA replicationF32GM143866 · NIGMS · ROCKEFELLER UNIVERSITY · PI RUIZ, PENELOPE LEE · 2021 to 2022
$136kNCI NIH HHS F30 CA268717NIGMS NIH HHS F32 GM143866NIGMS NIH HHS R01 GM140400NIGMS NIH HHS T32 GM007739NIGMS NIH HHS T32 GM066699
6 · The paper itselfAbstract
Genetic information is duplicated via the highly regulated process of DNA replication. The machinery coordinating this process, the replisome, encounters many challenges, including replication fork-stalling lesions that threaten the accurate and timely transmission of genetic information. Cells have multiple mechanisms to repair or bypass lesions that would otherwise compromise DNA replication
Identifiers
PMID36993543
PMCPMC10054921
OpenAlexW4324145915
What OpenQuestion holds
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