Evidence map›Paper›PMID 36993491›Full record

ArticlebioRxiv : the preprint server for biology2023

Intermediate filament dysregulation and astrocytopathy in the human disease model of

Rachel Battaglia, Maryam Faridounnia, Adriana Beltran, Jasmine Robinson, Karina Kinghorn, J Ashley Ezzell, Diana Bharucha-Goebel, Carsten Bonnemann, Jody E Hooper, Puneet Opal and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Rachel BattagliaDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Maryam FaridounniaDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Adriana BeltranDepartment of Genetics, University of North Carolina at Chapel Hill.
Jasmine RobinsonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Karina KinghornDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
J Ashley EzzellDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Diana Bharucha-GoebelNational Institute of Neurological Diseases and Stroke, Bethesda, MD.
Carsten BonnemannNational Institute of Neurological Diseases and Stroke, Bethesda, MD.
Jody E HooperDepartment of Pathology, Stanford University, Palo Alto, CA.
Puneet OpalDepartments of Neurology and Cell and Developmental Biology, Northwestern University, Chicago, IL.
Thomas W BouldinDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Diane ArmaoDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Natasha SniderDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
University of North Carolina at Chapel Hill · USNational Institute of Neurological Disorders and Stroke · USNorthwestern University · USPalo Alto University · US

Funding

Understanding the Cellular Basis of Movement DisordersR01NS082351 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Puneet Opal · 2013 to 2026
$6.2M
Elucidating cellular mechanisms underlying neurodegenerationR01NS127204 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Puneet Opal · 2022 to 2026
$2.8M
VEGF-Mimetic Supramolecular Nanoparticles for Treating Spinocerebellar Ataxia Type 1R61NS127141 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI OPAL, PUNEET, STUPP, SAMUEL I · 2023 to 2024
$763k
Intermediate Filament Proteostasis and RNA regulation in Giant Axonal NeuropathyR21NS121578 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARMAO, DIANE, SNIDER, NATASHA T · 2021 to 2022
$428k
Function of reactive astrocytes in aging and neurodegenerative diseaseF99AG068523 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATTAGLIA, RACHEL · 2020 to 2020
$31k
NIA NIH HHS F99 AG068523NINDS NIH HHS R01 NS082351NINDS NIH HHS R01 NS127204NINDS NIH HHS R21 NS121578NINDS NIH HHS R61 NS127141
6 · The paper itself

Abstract

Giant Axonal Neuropathy (GAN) is a pediatric neurodegenerative disease caused by

Identifiers

PMID36993491
PMCPMC10054982
OpenAlexW4324134198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.