Evidence map›Paper›PMID 36993484›Full record

ArticlebioRxiv : the preprint server for biology2023

Genetic and Environmental interactions contribute to immune variation in rewilded mice.

Oyebola Oyesola, Alexander E Downie, Nina Howard, Ramya S Barre, Kasalina Kiwanuka, Kimberly Zaldana, Ying-Han Chen, Arthur Menezes, Soo Ching Lee, Joseph Devlin and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Oyebola OyesolaLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.
Alexander E DownieDepartment of Ecology and Evolutionary Biology, Princeton University; Princeton, NJ, USA.
Nina HowardLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.
Ramya S BarreDepartment of Ecology and Evolutionary Biology, Princeton University; Princeton, NJ, USA.
Kasalina KiwanukaLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.
Kimberly ZaldanaLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.
Ying-Han ChenKimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine; New York, NY, USA.
Arthur MenezesDepartment of Ecology and Evolutionary Biology, Princeton University; Princeton, NJ, USA.
Soo Ching LeeLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.
Joseph DevlinKimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine; New York, NY, USA.
Octavio Mondragón-PalominoLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.
Camila Oliveira Silva SouzaLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.
Christin HerrmannKimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine; New York, NY, USA.
Sergei KoralovKimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine; New York, NY, USA.
Ken CadwellKimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine; New York, NY, USA.
Andrea L GrahamDepartment of Ecology and Evolutionary Biology, Princeton University; Princeton, NJ, USA.
P'ng LokeLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health; Bethesda, MD, USA.

Funding

New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Interactions between helminth colonization and the gut microbiotaR01AI130945 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA · 2018 to 2022
$3.3M
NCATS NIH HHS UL1 TR003017NIAID NIH HHS R01 AI130945
6 · The paper itself

Abstract

The relative and synergistic contributions of genetics and environment to inter-individual immune response variation remain unclear, despite its implications for understanding both evolutionary biology and medicine. Here, we quantify interactive effects of genotype and environment on immune traits by investigating three inbred mouse strains rewilded in an outdoor enclosure and infected with the parasite,

Identifiers

PMID36993484
PMCPMC10055251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.