Evidence map›Paper›PMID 36993447›Full record

ArticlebioRxiv : the preprint server for biology2023

Cysteine-Rich Intestinal Protein 1 is a Novel Surface Marker for Myometrial Stem/Progenitor Cells.

Emmanuel N Paul, Tyler J Carpenter, Sarah Fitch, Rachael Sheridan, Kin H Lau, Ripla Arora, Jose M Teixeira

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Emmanuel N PaulDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 48824, USA.
Tyler J CarpenterDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 48824, USA.
Sarah FitchDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 48824, USA.
Rachael SheridanFlow Cytometry Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Kin H LauBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Ripla AroraDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 48824, USA.
Jose M TeixeiraDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 48824, USA.
Michigan State University · USQuantitative BioSciences · USVan Andel Institute · US

Funding

Patient-specific targeting of uterine fibroidsR01HD096259 · NICHD · MICHIGAN STATE UNIVERSITY · PI TEIXEIRA, JOSE M. · 2019 to 2023
$2.4M
Myometrial stem cellsR21HD100959 · NICHD · MICHIGAN STATE UNIVERSITY · PI TEIXEIRA, JOSE M. · 2020 to 2021
$430k
NICHD NIH HHS R01 HD096259NICHD NIH HHS R21 HD100959
6 · The paper itself

Abstract

Myometrial stem/progenitor cells (MyoSPCs) have been proposed as the cells of origin for uterine fibroids, which are benign tumors that develop in the myometrium of most reproductive age women, but the identity of the MyoSPC has not been well established. We previously identified SUSD2 as a possible MyoSPC marker, but the relatively poor enrichment in stem cell characteristics of SUSD2+ over SUSD2- cells compelled us to find better discerning markers for more rigorous downstream analyses. We combined bulk RNA-seq of SUSD2+/- cells with single cell RNA-seq to identify markers capable of further enriching for MyoSPCs. We observed seven distinct cell clusters within the myometrium, with the vascular myocyte cluster most highly enriched for MyoSPC characteristics and markers, including

Identifiers

PMID36993447
PMCPMC10054937
OpenAlexW4321457349

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.