ArticlebioRxiv : the preprint server for biology2023
Esm-1 mediates transcriptional polarization associated with diabetic kidney disease.
Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors at 1 institution in 1 country.
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Abstract
Background: Esm-1, endothelial cell-specific molecule-1, is a susceptibility gene for diabetic kidney disease (DKD) and is a cytokine- and glucose-regulated, secreted proteoglycan, that is notably expressed in kidney and attenuates inflammation and albuminuria. Methods: We utilized publicly available single-cell RNA sequencing data to explore the characteristics of Results: In both mice and humans, Conclusions: A comprehensive analysis of single cell and bulk transcriptomes demonstrates that diabetes correlates with lower
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