Evidence map›Paper›PMID 36993420›Full record

ArticlebioRxiv : the preprint server for biology2023

Visualization of translation reorganization upon persistent collision stress in mammalian cells.

Juliette Fedry, Joana Silva, Mihajlo Vanevic, Stanley Fronik, Yves Mechulam, Emmanuelle Schmitt, Amédée des Georges, William Faller, Friedrich Förster

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Juliette FedryStructural Biochemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CG Utrecht, The Netherlands.
Joana SilvaDivision of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Mihajlo VanevicStructural Biochemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CG Utrecht, The Netherlands.
Stanley FronikStructural Biochemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CG Utrecht, The Netherlands.
Yves MechulamLaboratoire de Biologie Structurale de la Cellule, BIOC, Ecole polytechnique, CNRS, Institut Polytechnique de Paris, 91128 Palaiseau cedex, France.
Emmanuelle SchmittLaboratoire de Biologie Structurale de la Cellule, BIOC, Ecole polytechnique, CNRS, Institut Polytechnique de Paris, 91128 Palaiseau cedex, France.
Amédée des GeorgesStructural Biology Initiative, CUNY Advanced Science Research Center, City University of New York, New York, NY, USA.
William FallerDivision of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Friedrich FörsterStructural Biochemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CG Utrecht, The Netherlands.
Utrecht University · NLCentre National de la Recherche Scientifique · FRThe Netherlands Cancer Institute · NLThe Graduate Center, CUNY · US

Funding

Understanding membrane proteins’ allosteric modulation with cryo-EMR35GM133598 · NIGMS · NEW YORK UNIVERSITY · PI Amedee des Georges · 2019 to 2026
$3.4M
NIGMS NIH HHS R35 GM133598
6 · The paper itself

Abstract

Aberrantly slow mRNA translation leads to ribosome stalling and subsequent collision with the trailing neighbor. Ribosome collisions have recently been shown to act as stress sensors in the cell, with the ability to trigger stress responses balancing survival and apoptotic cell-fate decisions depending on the stress level. However, we lack a molecular understanding of the reorganization of translation processes over time in mammalian cells exposed to an unresolved collision stress. Here we visualize the effect of a persistent collision stress on translation using

Identifiers

PMID36993420
PMCPMC10055323
OpenAlexW4360823149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.