Evidence map›Paper›PMID 36993413›Full record

ArticlebioRxiv : the preprint server for biology2023

Insufficient evidence for natural selection associated with the Black Death.

Alison R Barton, Cindy G Santander, Pontus Skoglund, Ida Moltke, David Reich, Iain Mathieson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Alison R BartonDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Cindy G SantanderDepartment of Biology, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Pontus SkoglundAncient Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Ida MoltkeDepartment of Biology, University of Copenhagen, Copenhagen, DK-2200, Denmark.
David ReichDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Iain MathiesonDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.
University of Copenhagen · DKBroad Institute · USHarvard University · USThe Francis Crick Institute · GBUniversity of Pennsylvania · US

Funding

Polygenic prediction and evolution of complex traitsR35GM133708 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Iain Neil Mathieson · 2019 to 2026
$2.9M
Solving ascertainment bias in ancient DNA using Ultima Genomics sequencingR01HG012287 · NHGRI · HARVARD MEDICAL SCHOOL · PI REICH, DAVID E · 2021 to 2025
$2.7M
NHGRI NIH HHS R01 HG012287NIGMS NIH HHS R35 GM133708Wellcome Trust FC001595
6 · The paper itself

Abstract

Klunk et al. analyzed ancient DNA data from individuals in London and Denmark before, during and after the Black Death [1], and argued that allele frequency changes at immune genes were too large to be produced by random genetic drift and thus must reflect natural selection. They also identified four specific variants that they claimed show evidence of selection including at

Identifiers

PMID36993413
PMCPMC10055098
OpenAlexW4327612769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.