Evidence map›Paper›PMID 36993386›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Rapid emergence and transmission of virulence-associated mutations in the oral poliovirus vaccine following vaccination campaigns.

Katharine S Walter, Jonathan Altamirano, ChunHong Huang, Yuan J Carrington, Frank Zhou, Jason R Andrews, Yvonne Maldonado

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katharine S WalterDivision of Epidemiology, University of Utah, Salt Lake City, UT 84105, USA.
Jonathan AltamiranoDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA 94305, USA.
ChunHong HuangDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Yuan J CarringtonDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Frank ZhouDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Jason R AndrewsDivision of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yvonne MaldonadoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · USUniversity of Utah · US

Funding

A genomic tool for identifying pathogenic circulating vaccine-derivedpoliovirusesR21AI148810 · NIAID · STANFORD UNIVERSITY · PI MALDONADO, YVONNE A. · 2020 to 2021
$434k
NIAID NIH HHS R21 AI148810
6 · The paper itself

Abstract

There is an increasing burden of circulating vaccine-derived polioviruses (cVDPVs) due to the continued use of oral poliovirus vaccine (OPV). However, the informativeness of routine OPV VP1 sequencing for the early identification of viruses carrying virulence-associated reversion mutations has not been directly evaluated in a controlled setting. We prospectively collected 15,331 stool samples to track OPV shedding from vaccinated children and their contacts for ten weeks following an immunization campaign in Veracruz State, Mexico and sequenced VP1 genes from 358 samples. We found that OPV was genetically unstable and evolves at an approximately clocklike rate that varies across serotypes and by vaccination status. Alarmingly, 28% (13/47) of OPV-1, 12% (14/117) OPV-2, and 91% (157/173) OPV-3 of Sabin-like viruses had ≥1 known reversion mutation. Our results suggest that current definitions of cVDPVs may exclude circulating virulent viruses that pose a public health risk and underscore the need for intensive surveillance following OPV use.

Identifiers

PMID36993386
PMCPMC10055580
OpenAlexW4328089977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.