Evidence map›Paper›PMID 36993355›Full record

ArticlebioRxiv : the preprint server for biology2023

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.

Natasha I Edman, Rachel L Redler, Ashish Phal, Thomas Schlichthaerle, Sanjay R Srivatsan, Ali Etemadi, Seong J An, Andrew Favor, Devon Ehnes, Zhe Li and 22 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Natasha I EdmanDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Rachel L RedlerDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Ashish PhalInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
Thomas SchlichthaerleDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Sanjay R SrivatsanInstitute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Ali EtemadiDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Seong J AnDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Andrew FavorDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Devon EhnesDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Zhe LiDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Florian PraetoriusDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Max GordonDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Wei YangDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Brian CoventryDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Derrick R HicksDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Longxing CaoDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Neville BethelDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Piper HeineDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Analisa MurrayDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Stacey GerbenDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Lauren CarterDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Marcos MirandaDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Babak NegahdariMedical Biotechnology Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Sangwon LeeDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Cole TrapnellDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Lance StewartDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Damian C EkiertDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Joseph SchlessingerDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Gira BhabhaDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
Hannele Ruohola-BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Progenitor Cell Biology Consortium Administrative Coordinating CenterU01HL099997 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2009 to 2015
$29.9M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Self Renewal and Differentiation of Human Embryonic Stem CellsP01GM081619 · NIGMS · UNIVERSITY OF WASHINGTON · PI REH, THOMAS A · 2007 to 2017
$20.6M
Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI TIAN, LU · 2020 to 2024
$15.9M
Controlling Hematopoietic Lineage Commitment from ESC to PlateletsU01HL099993 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TOROK-STORB, BEVERLY J. · 2009 to 2015
$8.3M
Comprehensive Training in Inter-Disciplinary Oral Health ResearchT90DE021984 · NIDCR · UNIVERSITY OF WASHINGTON · PI Robert Aaron Cornell · 2012 to 2026
$7.9M
Unravelling lipid trafficking for the bacterial outer membraneR35GM128777 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Damian Ekiert · 2018 to 2026
$4.1M
Designed Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5M
MicroRNA Function in Human Embryonic Stem CellsR01GM083867 · NIGMS · UNIVERSITY OF WASHINGTON · PI RUOHOLA-BAKER, HANNELE · 2008 to 2011
$1.5M
Acquisition of Embryonic Stem Cell Metabolic Signature - Minority SupplementR01GM097372 · NIGMS · UNIVERSITY OF WASHINGTON · PI RUOHOLA-BAKER, HANNELE · 2011 to 2014
$1.3M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
NHLBI NIH HHS U01 HL099993NHLBI NIH HHS U01 HL099997NIA NIH HHS R01 AG063845NIA NIH HHS U19 AG065156NIDCR NIH HHS T90 DE021984NIGMS NIH HHS P01 GM081619NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM083867NIGMS NIH HHS R01 GM097372NIGMS NIH HHS R35 GM128777NIGMS NIH HHS U24 GM129539NIH HHS S10 OD018483
6 · The paper itself

Abstract

Growth factors and cytokines signal by binding to the extracellular domains of their receptors and drive association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling cascades. To enable systematic exploration of how receptor valency and geometry affects signaling outcomes, we designed cyclic homo-oligomers with up to 8 subunits using repeat protein building blocks that can be modularly extended. By incorporating a

Indexed as

binder designcryo-EMDe novo protein designendothelial cell differentiationFGF signalingiPSCsoligomeric scaffolds

Identifiers

PMID36993355
PMCPMC10055045

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.