Evidence map›Paper›PMID 36993332›Full record

ArticlebioRxiv : the preprint server for biology2023

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and

Sudeshna Das, Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Aicha Abdourahman, Joseph A Tamm, Maya E Woodbury, Robert V Talanian, Knut Biber and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Sudeshna DasMassachusetts General Hospital, Neurology Dept. Boston, MA 02114.
Zhaozhi LiMassachusetts General Hospital, Neurology Dept. Boston, MA 02114.
Astrid WachterAbbVie Deutschland GmbH & Co. KG, Genomics Research Center, Knollstrasse, 67061 Ludwigshafen.
Srinija AllaMassachusetts General Hospital, Neurology Dept. Boston, MA 02114.
Ayush NooriMassachusetts General Hospital, Neurology Dept. Boston, MA 02114.
Aicha AbdourahmanAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139.
Joseph A TammAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139.
Maya E WoodburyAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139.
Robert V TalanianAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139.
Knut BiberAbbVie Deutschland GmbH & Co. KG, Neuroscience Research Center, Knollstrasse, 67061 Ludwigshafen.
Eric H KarranAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139.
Bradley T HymanMassachusetts General Hospital, Neurology Dept. Boston, MA 02114.
Alberto Serrano-PozoMassachusetts General Hospital, Neurology Dept. Boston, MA 02114.ORCID 0000-0003-0899-7530
AbbVie (United States) · USHarvard University · USMassachusetts General Hospital · USAbbVie (Germany) · DE

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Are multiple tau species toxic in Alzheimer's Disease?RF1AG059789 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 2018 to 2018
$2.7M
Synergy between amyloid and tau in Alzheimer's DiseaseRF1AG058674 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 2018 to 2018
$2.6M
Astrocyte Reaction in Alzheimer's DiseaseK08AG064039 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SERRANO-POZO, ALBERTO · 2019 to 2023
$837k
Complexity and Heterogeneity of Alzheimer diseaseR56AG061196 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 2019 to 2019
$654k
NIA NIH HHS K08 AG064039NIA NIH HHS P30 AG062421NIA NIH HHS R56 AG061196NIA NIH HHS RF1 AG058674NIA NIH HHS RF1 AG059789
6 · The paper itself

Abstract

introductionOmics studies have revealed that various brain cell types undergo profound molecular changes in Alzheimer's disease (AD) but the spatial relationships with plaques and tangles and

methodsWe performed laser capture microdissection of Aβ plaques, the 50μm halo around them, tangles with the 50μm halo around them, and areas distant (>50μm) from plaques and tangles in the temporal cortex of AD and control donors, followed by RNA-sequencing.

resultsAβ plaques exhibited upregulated microglial (neuroinflammation/phagocytosis) and downregulated neuronal (neurotransmission/energy metabolism) genes, whereas tangles had mostly downregulated neuronal genes. Aβ plaques had more differentially expressed genes than tangles. We identified a gradient Aβ plaque>peri-plaque>tangle>distant for these changes. AD DISCUSSION: Transcriptomic changes in AD consist primarily of neuroinflammation and neuronal dysfunction, are spatially associated mainly with Aβ plaques, and are exacerbated by the

Identifiers

PMID36993332
PMCPMC10055287
OpenAlexW4328052654

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.