Evidence map›Paper›PMID 36993323›Full record

ArticleResearch square2023

Isabel Espadas, Jenna Wingfield, Eddie Grinman, Ilika Ghosh, Kaushik Chanda, Yoshihisa Nakahata, Karl Bauer, Bindu Raveendra, Michael Kiebler, Ryohei Yasuda and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Isabel EspadasDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Jenna WingfieldDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Eddie GrinmanDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Ilika GhoshMax Planck Florida Institute, Jupiter, FL, USA.
Kaushik ChandaDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Yoshihisa NakahataMax Planck Florida Institute, Jupiter, FL, USA.
Karl BauerBiomedical Center (BMC), Department for Cell Biology, Medical Faculty, Ludwig-Maximilians-University of Munich, 82152 Planegg-Martinsried, Germany.
Bindu RaveendraDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Michael KieblerBiomedical Center (BMC), Department for Cell Biology, Medical Faculty, Ludwig-Maximilians-University of Munich, 82152 Planegg-Martinsried, Germany.
Ryohei YasudaMax Planck Florida Institute, Jupiter, FL, USA.ORCID 0000-0001-6263-9297
Vidhya RangarajuMax Planck Florida Institute, Jupiter, FL, USA.ORCID 0000-0002-6716-4312
Sathyanarayanan PuthanveettilDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID 0000-0002-1302-6766
Scripps (United States) · USMax Planck Florida Institute for Neuroscience · USBernstein Center for Computational Neuroscience Munich · DELudwig-Maximilians-Universität München · DE

Funding

Transcriptomic Mechanisms of Formation and Persistence of Synapse Specific Long-Term MemoryR01MH119541 · NIMH · UNIVERSITY OF FLORIDA · PI PUTHANVEETTIL, SATHYA · 2019 to 2023
$2.7M
Axonal Transport and Long-Term Memory StorageR01MH094607 · NIMH · SCRIPPS FLORIDA · PI PUTHANVEETTIL, SATHYA · 2014 to 2018
$2.3M
Hippocampal IncRNAs and Memory ConsolidationR21DA039417 · NIDA · SCRIPPS FLORIDA · PI PUTHANVEETTIL, SATHYA · 2016 to 2017
$528k
Novel role of mitotic kinesin KIF11 in structural plasticity and memoryF32MH131420 · NIMH · UNIVERSITY OF FLORIDA · PI WINGFIELD, JENNA LYNNE · 2022 to 2023
$139k
NIDA NIH HHS R21 DA039417NIMH NIH HHS F32 MH131420NIMH NIH HHS R01 MH094607NIMH NIH HHS R01 MH119541
6 · The paper itself

Abstract

LncRNAs are involved in critical processes for cell homeostasis and function. However, it remains largely unknown whether and how the transcriptional regulation of long noncoding RNAs results in activity-dependent changes at the synapse and facilitate formation of long-term memories. Here, we report the identification of a novel lncRNA, SLAMR, that becomes enriched in CA1- but not in CA3-hippocampal neurons upon contextual fear conditioning. SLAMR is transported to dendrites via the molecular motor KIF5C and recruited to the synapse in response to stimulation. Loss of function of SLAMR reduced dendritic complexity and impaired activity dependent changes in spine structural plasticity. Interestingly, gain of function of SLAMR enhanced dendritic complexity, and spine density through enhanced translation. Analyses of the SLAMR interactome revealed its association with CaMKIIα protein through a 220-nucleotide element and its modulation of CaMKIIα activity. Furthermore, loss-of-function of SLAMR in CA1 selectively impairs consolidation but neither acquisition, recall, nor extinction of fear memory and spatial memory. Together, these results establish a new mechanism for activity dependent changes at the synapse and consolidation of contextual fear.

Indexed as

hippocampusKIF5ClncRNAmemoryplasticitytransport

Identifiers

PMID36993323
PMCPMC10055528
OpenAlexW4324143011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.