ArticlebioRxiv : the preprint server for biology2023
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
Jerika J Barron, Nicholas M Mroz, Sunrae E Taloma, Madelene W Dahlgren, Jorge Ortiz-Carpena, Leah C Dorman, Ilia D Vainchtein, Caroline C Escoubas, Ari B Molofsky, Anna V Molofsky
Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
Jerika J BarronDepartments of Psychiatry/Weill Institute for Neurosciences.
Nicholas M MrozBiomedical Sciences Graduate Program.
Sunrae E TalomaDepartments of Psychiatry/Weill Institute for Neurosciences.
Madelene W DahlgrenDepartment of Laboratory Medicine. University of California, San Francisco, San Francisco, CA.
Jorge Ortiz-CarpenaDepartment of Laboratory Medicine. University of California, San Francisco, San Francisco, CA.
Leah C DormanDepartments of Psychiatry/Weill Institute for Neurosciences.
Ilia D VainchteinDepartments of Psychiatry/Weill Institute for Neurosciences.
Caroline C EscoubasDepartments of Psychiatry/Weill Institute for Neurosciences.
Ari B MolofskyDepartment of Laboratory Medicine. University of California, San Francisco, San Francisco, CA.
Anna V MolofskyDepartments of Psychiatry/Weill Institute for Neurosciences.
University of California, San Francisco · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
Microglial remodeling of the extracellular matrix in memory circuitsR01MH125000 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2021 to 2025
$3.3M
Localization and function of tissue type 2 lymphocytes during mixed inflammationR01AI162806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ari B Molofsky · 2022 to 2026
$2.8M
Defining group 2 innate lymphoid cell lung nichesR01HL142701 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ARI B · 2019 to 2022
$2.5M
Meningeal type 2 immunity in cortical synapse remodeling during brain development and injuryR01NS126765 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anna V Molofsky, Ari B Molofsky · 2022 to 2026
$2.3M
Astrocyte-microglial communication in developmental synapse formationR01MH119349 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2019 to 2023
$2.0M
BD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573k
Defining lymphocyte-microglia crosstalk during cortical synapse developmentF31MH122207 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARRON, JERIKA JANET · 2020 to 2021
The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required for cortical inhibitory synapse maturation and adult social behavior. ILC2s expanded in the developing meninges and produced a surge of their canonical cytokine Interleukin-13 (IL-13) between postnatal days 5-15. Loss of ILC2s decreased cortical inhibitory synapse numbers in the postnatal period where as ILC2 transplant was sufficient to increase inhibitory synapse numbers. Deletion of the IL-4/IL-13 receptor (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior. · full record | OpenQuestion