Evidence map›Paper›PMID 36993274›Full record

ArticlebioRxiv : the preprint server for biology2023

Proteomic survey of the DNA damage response in

Tommy F Tashjian, Rilee D Zeinert, Stephen J Eyles, Peter Chien

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tommy F TashjianDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.
Rilee D ZeinertDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.
Stephen J EylesDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.
Peter ChienDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.
University of Massachusetts Amherst · US

Funding

Regulated Proteolysisin Bacteria Development and Stress ResponseR35GM130320 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Peter Chien · 2019 to 2026
$3.4M
NIGMS NIH HHS R35 GM130320
6 · The paper itself

Abstract

The bacterial DNA damage response is a critical, coordinated response to endogenous and exogenous sources of DNA damage. Response dynamics are dependent on coordinated synthesis and loss of relevant proteins. While much is known about its global transcriptional control, changes in protein abundance that occur upon DNA damage are less well characterized at the system level. Here, we perform a proteome-wide survey of the DNA damage response in IMPORTANCE: The DNA damage response helps bacteria to react to and potentially survive DNA damage. The mutagenesis induced during this stress response contributes to the development of antibiotic resistance. Understanding how bacteria coordinate their response to DNA damage could help us to combat this growing threat to human health. While the transcriptional regulation of the bacterial DNA damage response has been characterized, this study is the first to our knowledge to assess the proteomic response to DNA damage in

Identifiers

PMID36993274
PMCPMC10055390
OpenAlexW4360942798

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.