Evidence map›Paper›PMID 36993273›Full record

ArticlebioRxiv : the preprint server for biology2023

Lipoarabinomannan regulates septation in

Ian L Sparks, Japinder Nijjer, Jing Yan, Yasu S Morita

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ian L SparksDepartment of Microbiology, University of Massachusetts, Amherst, MA, USA.
Japinder NijjerDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven CT, USA.
Jing YanDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven CT, USA.
Yasu S MoritaDepartment of Microbiology, University of Massachusetts, Amherst, MA, USA.
University of Massachusetts Amherst · USYale University · US

Funding

Tracking single-cell gene expression heterogeneity and its consequences in bacterial biofilmsDP2GM146253 · NIGMS · YALE UNIVERSITY · PI YAN, JING · 2021 to 2024
$2.5M
Cell envelope integrity in mycobacteria: interplay of lipoglycans, peptidoglycan, and capsular polysaccharidesR21AI168791 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MORITA, YASU S · 2023 to 2024
$420k
NIAID NIH HHS R21 AI168791NIGMS NIH HHS DP2 GM146253
6 · The paper itself

Abstract

The growth and division of mycobacteria, which include several clinically relevant pathogens, deviate significantly from that of canonical bacterial models. Despite their Gram-positive ancestry, mycobacteria synthesize and elongate a diderm envelope asymmetrically from the poles, with the old pole elongating more robustly than the new pole. In addition to being structurally distinct, the molecular components of the mycobacterial envelope are also evolutionarily unique, including the phosphatidylinositol-anchored lipoglycans lipomannan (LM) and lipoarabinomannan (LAM). LM and LAM modulate host immunity during infection, but their role outside of intracellular survival remains poorly understood, despite their widespread conservation among non-pathogenic and opportunistically pathogenic mycobacteria. Previously,

Indexed as

cell divisioncell shapelipoglycanmannosyltransferaseMycobacterium

Identifiers

PMID36993273
PMCPMC10055410
OpenAlexW4360982540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.