Evidence map›Paper›PMID 36993266›Full record

ArticlebioRxiv : the preprint server for biology2023

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow.

By Meeki Lad, Angad S Beniwal, Saket Jain, Poojan Shukla, Jangham Jung, Sumedh S Shah, Garima Yagnik, Husam Babikir, Alan T Nguyen, Sabraj Gill and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

By Meeki LadORCID 0000-0002-3920-5551
Angad S Beniwal
Saket JainORCID 0000-0002-8655-2951
Poojan Shukla
Jangham JungORCID 0000-0003-2806-3698
Sumedh S ShahORCID 0000-0002-8644-4993
Garima YagnikORCID 0000-0001-8541-2546
Husam BabikirORCID 0000-0002-3940-047X
Alan T Nguyen
Sabraj Gill
Jacob S YoungORCID 0000-0002-5499-4325
Austin LuiORCID 0000-0003-1347-8815
Diana Salha
Aaron Diaz
Manish K AghiORCID 0000-0002-2949-2227
University of California, San Francisco · US

Funding

Tumor cell and microenvironment changes causing antiangiogenic therapy resistanceR01NS079697 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGHI, MANISH · 2013 to 2021
$3.2M
Modeling and druggable-genome screening of glioblastoma invasion using regional biopsy-guided biomaterials systemsR01CA227136 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGHI, MANISH · 2018 to 2022
$2.2M
Retroviral RLI immunomodulatory gene therapy for glioblastomaR01NS123808 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Manish Aghi · 2022 to 2026
$2.1M
An informatics framework for single-cell multi-omics from clinical specimensR01LM013897 · NLM · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aaron Antonio Diaz · 2022 to 2026
$1.8M
NCI NIH HHS R01 CA227136NINDS NIH HHS R01 NS079697NINDS NIH HHS R01 NS123808NLM NIH HHS R01 LM013897
6 · The paper itself

Abstract

Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that 'hybrid' neutrophils with dendritic features - including morphological complexity, expression of antigen presentation genes, and the ability to process exogenous peptide and stimulate MHCII-dependent T cell activation - accumulate intratumorally and suppress tumor growth

Identifiers

PMID36993266
PMCPMC10055347
OpenAlexW4360943415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.