Evidence map›Paper›PMID 36993256›Full record

ArticlebioRxiv : the preprint server for biology2023

Inhibitory input directs astrocyte morphogenesis through glial GABA

Yi-Ting Cheng, Estefania Luna-Figueroa, Junsung Woo, Hsiao-Chi Chen, Zhung-Fu Lee, Akdes Serin Harmanci, Benjamin Deneen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yi-Ting ChengCenter for Cancer Neuroscience, Baylor College of Medicine, Houston TX 77030.
Estefania Luna-FigueroaCenter for Cancer Neuroscience, Baylor College of Medicine, Houston TX 77030.
Junsung WooCenter for Cancer Neuroscience, Baylor College of Medicine, Houston TX 77030.
Hsiao-Chi ChenCenter for Cancer Neuroscience, Baylor College of Medicine, Houston TX 77030.
Zhung-Fu LeeCenter for Cancer Neuroscience, Baylor College of Medicine, Houston TX 77030.
Akdes Serin HarmanciCenter for Cancer Neuroscience, Baylor College of Medicine, Houston TX 77030.
Benjamin DeneenCenter for Cancer Neuroscience, Baylor College of Medicine, Houston TX 77030.
Baylor College of Medicine · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Transcriptional regulation of gliogenesis in the CNSR01NS071153 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2010 to 2022
$5.0M
MOLECULAR AND CELLULAR CONTROL OF INJURY-INDUCED ASTROGENESISR01NS096096 · NINDS · DUKE UNIVERSITY · PI DENEEN, BENJAMIN · 2017 to 2021
$2.6M
Defining Roles for Astrocyte Subpopulations in the Aging BrainR01AG071687 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2021 to 2025
$2.0M
High Throughput Genomic Sequencer at BCM Core FacilityS10OD023469 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2017 to 2017
$600k
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Acquisition of 10X Genomics Chromium Instrument to Accelerate Genomic and Single Cell Transcriptomic ResearchS10OD025240 · OD · BAYLOR COLLEGE OF MEDICINE · PI DODDAPANENI, HARSHA VARDHAN · 2018 to 2018
$125k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NEI NIH HHS P30 EY002520NIA NIH HHS R01 AG071687NICHD NIH HHS P50 HD103555NIH HHS S10 OD023469NIH HHS S10 OD025240NINDS NIH HHS R01 NS071153NINDS NIH HHS R01 NS096096
6 · The paper itself

Abstract

Communication between neurons and glia plays an important role in establishing and maintaining higher order brain function. Astrocytes are endowed with complex morphologies which places their peripheral processes in close proximity to neuronal synapses and directly contributes to their regulation of brain circuits. Recent studies have shown that excitatory neuronal activity promotes oligodendrocyte differentiation; whether inhibitory neurotransmission regulates astrocyte morphogenesis during development is unknown. Here we show that inhibitory neuron activity is necessary and sufficient for astrocyte morphogenesis. We found that input from inhibitory neurons functions through astrocytic GABA

Identifiers

PMID36993256
PMCPMC10054985
OpenAlexW4324324979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.