Evidence map›Paper›PMID 36993244›Full record

ArticlebioRxiv : the preprint server for biology2023

Surfactant protein A promotes atherosclerosis through mediating macrophage foam cell formation.

Skylar D King, Dunpeng Cai, Mikayla M Fraunfelder, Shi-You Chen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Skylar D KingORCID 0000-0002-4150-7807
Dunpeng CaiORCID 0000-0002-0489-6567
Mikayla M Fraunfelder
Shi-You Chen
University of Missouri · US

Funding

Fortilin, p53, and atherosclerosisR01HL117247 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHEN, SHIYOU, FUJISE, KEN · 2013 to 2023
$4.7M
Novel mechanism of smooth muscle phenotypic modulation and vascular remodelingR01HL119053 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2023
$3.8M
Dedicator of cytokinesis 2 in abdominal aortic aneurysmR01HL147313 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2019 to 2022
$2.1M
The mechanistic role of surfactant protein A in smooth muscle cell phenotype modulation and vascular remodelingF32HL159930 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI KING, SKYLAR DAWN · 2021 to 2024
$249k
Novel Mechanisms Underlying the Development of AtherosclerosisI01BX006161 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI Shiyou Chen · 2023 to 2026
–
BLRD VA I01 BX006161NHLBI NIH HHS F32 HL159930NHLBI NIH HHS L30 HL170340NHLBI NIH HHS R01 HL117247NHLBI NIH HHS R01 HL119053NHLBI NIH HHS R01 HL147313
6 · The paper itself

Abstract

backgroundAtherosclerosis is a progressive inflammatory disease where macrophage foam cells play a central role in the pathogenesis. Surfactant protein A (SPA) is a lipid-associating protein involved with regulating macrophage function in various inflammatory diseases. However, the role of SPA in atherosclerosis and macrophage foam cell formation has not been investigated.

methodsPrimary resident peritoneal macrophages were extracted from wildtype (WT) and SPA deficient (SPA

results

conclusionsOur results elucidate that SPA is a novel factor for atherosclerosis development. SPA enhances macrophage foam cell formation and atherosclerosis through increasing scavenger receptor cluster of differentiation antigen 36 (CD36) expression.

Identifiers

PMID36993244
PMCPMC10055352
OpenAlexW4360822854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.