Evidence map›Paper›PMID 36993230›Full record

ArticlebioRxiv : the preprint server for biology2023

B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an

Chad H Hogan, Shana M Owens, Glennys V Reynoso, Varvara Kirillov, Thomas J Meyer, Monika A Zelazowska, Bin Liu, Xiaofan Li, Aniska Chikhalya, Qiwen Dong and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Chad H HoganGraduate Program in Genetics, Stony Brook University, Stony Brook, New York, USA.
Shana M OwensDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Glennys V ReynosoViral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Varvara KirillovDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Thomas J MeyerCCR Collaborative Bioinformatics Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Monika A ZelazowskaDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bin LiuDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xiaofan LiHIV & AIDS Malignancy Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
Aniska ChikhalyaDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Qiwen DongDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Camille KhairallahDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Nancy C ReichDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Brian SheridanDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Kevin M McBrideDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Patrick HearingDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Heather D HickmanViral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
J Craig ForrestDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Laurie T KrugHIV & AIDS Malignancy Branch, National Cancer Institute, NIH, Bethesda, MD, USA.
Stony Brook School · USThe University of Texas MD Anderson Cancer Center · USNational Cancer Institute · USNational Institute of Allergy and Infectious Diseases · USUniversity of Arkansas for Medical Sciences · USNational Institutes of Health · US

Funding

Imaging Antiviral ImmunityZIAAI001225 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HICKMAN, HEATHER · 2017 to 2025
$11.4M
Investigation of viral and host determinants of gammaherpesvirus pathogenesisZIABC011953 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRUG, LAURIE TATE · 2020 to 2025
$8.1M
Regulation of Nuclear Signaling Pathways by the Adenovirus E4-ORF3 ProteinR01CA122677 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HEARING, PATRICK · 2007 to 2022
$5.2M
Gammaherpesvirus interactions with host tumor suppressor p53R01CA167065 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI James Craig Forrest · 2014 to 2026
$3.8M
Functional Analysis of STAT3 in Gammaherpesvirus InfectionR01AI119079 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI REICH MARSHALL, NANCY C. · 2015 to 2019
$2.2M
J. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5M
Defining the efficacy of replication-dead viruses as gammaherpesvirus vaccinesR21AI139580 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI FORREST, JAMES CRAIG · 2019 to 2020
$440k
NCATS NIH HHS TL1 TR003109NCI NIH HHS R01 CA122677NCI NIH HHS R01 CA167065NIAID NIH HHS R01 AI119079NIAID NIH HHS R21 AI139580
6 · The paper itself

Abstract

Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription factor STAT3. To better understand the role of STAT3 during gammaherpesvirus latency and immune control, we utilized murine gammaherpesvirus 68 (MHV68) infection. Genetic deletion of STAT3 in B cells of

Identifiers

PMID36993230
PMCPMC10055336
OpenAlexW4360618422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.