Evidence map›Paper›PMID 36993224›Full record

ArticlebioRxiv : the preprint server for biology2023

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.

Pooja Srinivas, Meisam Nosrati, Natalia Zelinskaya, Debayan Dey, Lindsay R Comstock, Christine M Dunham, Graeme L Conn

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pooja SrinivasDepartment of Chemistry, Emory University, Atlanta, Georgia, 30322, USA.
Meisam NosratiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Natalia ZelinskayaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Debayan DeyDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Lindsay R ComstockDepartment of Chemistry, Wake Forest University, 455 Vine Street, Wake Downtown, Winston-Salem, North Carolina, 27101, USA.
Christine M DunhamDepartment of Chemistry, Emory University, Atlanta, Georgia, 30322, USA.
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Emory University · USWake Forest University · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
RNA modification and antibiotic resistanceR01AI088025 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Christine M Dunham · 2010 to 2026
$7.9M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
NIAID NIH HHS R01 AI088025NIAID NIH HHS T32 AI106699NIGMS NIH HHS T32 GM008602NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the aminoglycoside-resistance 16S rRNA (m

Identifiers

PMID36993224
PMCPMC10054953
OpenAlexW4324147310

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.