ArticlebioRxiv : the preprint server for biology2023
A comprehensive map of hotspots of de novo telomere addition in
Katrina Ngo, Tristen H Gittens, David I Gonzalez, E Anne Hatmaker, Simcha Plotkin, Mason Engle, Geofrey A Friedman, Melissa Goldin, Remington E Hoerr, Brandt F Eichman and 3 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors at 2 institutions in 1 country.
Katrina NgoDepartment of Biological Sciences, Vanderbilt University.
Tristen H GittensDepartment of Biological Sciences, Vanderbilt University.
David I GonzalezDepartment of Biological Sciences, Vanderbilt University.
E Anne HatmakerDepartment of Biological Sciences, Vanderbilt University.
Simcha PlotkinDepartment of Biological Sciences, Vanderbilt University.
Mason EngleDepartment of Biological Sciences, Vanderbilt University.
Geofrey A FriedmanDepartment of Biological Sciences, Vanderbilt University.
Melissa GoldinDepartment of Biological Sciences, Vanderbilt University.
Remington E HoerrDepartment of Biological Sciences, Vanderbilt University.
Brandt F EichmanDepartment of Biological Sciences, Vanderbilt University.
Antonis RokasDepartment of Biological Sciences, Vanderbilt University.
Mary Lauren BentonDepartment of Computer Science, Baylor University.
Katherine L FriedmanDepartment of Biological Sciences, Vanderbilt University.
Vanderbilt University · USBaylor University · US
Funding
The DNA replication-repair interface: mechanisms and regulationR35GM136401 · NIGMS · VANDERBILT UNIVERSITY · PI Brandt F Eichman · 2020 to 2026
$4.3MDeciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5MCellular, Biochemical and Molecular Sciences Training ProgramT32GM137793 · NIGMS · VANDERBILT UNIVERSITY · PI Katherine Louise Friedman, TODD R GRAHAM · 2021 to 2026
$2.6MMARC at Vanderbilt UniversityT34GM136451 · NIGMS · VANDERBILT UNIVERSITY · PI FRIEDMAN, KATHERINE LOUISE, MCMAHON, DOUGLAS G · 2020 to 2024
$2.0MHotspots of de novo telomere addition as mediators of genomic instability in yeastR01GM123292 · NIGMS · VANDERBILT UNIVERSITY · PI FRIEDMAN, KATHERINE LOUISE · 2017 to 2020
$1.3MExamining the role of opportunistic human pathogen Aspergillus flavus in fungal keratitis eye infectionsF31EY033235 · NEI · VANDERBILT UNIVERSITY · PI HATMAKER, ELIZABETH ANNE · 2022 to 2023
$42kNEI NIH HHS F31 EY033235NIAID NIH HHS R01 AI153356NIGMS NIH HHS R01 GM123292NIGMS NIH HHS R35 GM136401NIGMS NIH HHS T32 GM137793NIGMS NIH HHS T34 GM136451
6 · The paper itselfAbstract
Telomere healing occurs when telomerase, normally restricted to chromosome ends, acts upon a double-strand break to create a new, functional telomere. De novo telomere addition on the centromere-proximal side of a break truncates the chromosome but, by blocking resection, may allow the cell to survive an otherwise lethal event. We previously identified several sequences in the baker’s yeast,
Identifiers
PMID36993206
PMCPMC10055226
OpenAlexW4360865304
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390