Evidence map›Paper›PMID 36993194›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Mapping the dynamic genetic regulatory architecture of

Joyce B Kang, Amber Z Shen, Saori Sakaue, Yang Luo, Saisriram Gurajala, Aparna Nathan, Laurie Rumker, Vitor R C Aguiar, Cristian Valencia, Kaitlyn Lagattuta and 18 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 5 institutions in 4 countries.

Joyce B KangCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Amber Z ShenCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Saori SakaueCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Yang LuoCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Saisriram GurajalaCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Aparna NathanCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Laurie RumkerCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Vitor R C AguiarProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cristian ValenciaCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Kaitlyn LagattutaCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Fan ZhangCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Anna Helena JonssonDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Seyhan YazarGarvan Institute of Medical Research, Sydney, NSW, Australia.
Jose Alquicira-HernandezGarvan Institute of Medical Research, Sydney, NSW, Australia.
Hamed KhaliliDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ashwin N AnanthakrishnanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Karthik JagadeeshHarvard T. H. Chan School of Public Health, Boston, MA, USA.
Kushal DeyHarvard T. H. Chan School of Public Health, Boston, MA, USA.
Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network
Mark J DalyPsychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Ramnik J XavierKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Laura T DonlinHospital for Special Surgery, New York, NY, USA.
Jennifer H AnolikDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Joseph E PowellGarvan Institute of Medical Research, Sydney, NSW, Australia.
Deepak A RaoDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Michael B BrennerDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Maria Gutierrez-ArcelusProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Soumya RaychaudhuriCenter for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Broad Institute · USHarvard University · USBrigham and Women's Hospital · USGarvan Institute of Medical Research · AUHospital for Special Surgery · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1991 to 2026
$35.3M
Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
MECHANISMS OF ARTHRITIC &DERMATOLOGY DISORDERST32AR007530 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner, Ellen M Gravallese · 1986 to 2026
$10.4M
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4M
Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC)UC2AR081023 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2022 to 2026
$4.8M
Predicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2M
Characterizing the Genomic Basis of Immune-Mediated Resilience Against Tuberculosis in an Admixed Peruvian PopulationF30AI157385 · NIAID · HARVARD MEDICAL SCHOOL · PI RUMKER, LAURIE ANN · 2021 to 2024
$178k
Pinpointing how single-cell states affect genetic regulation of HLA expression in autoimmune diseasesF30AI172238 · NIAID · HARVARD MEDICAL SCHOOL · PI KANG, JOYCE BLOSSOM · 2022 to 2024
$143k
NHGRI NIH HHS T32 HG002295NHGRI NIH HHS U01 HG012009NIAID NIH HHS F30 AI157385NIAID NIH HHS F30 AI172238NIAMS NIH HHS R01 AR063759NIAMS NIH HHS T32 AR007530NIAMS NIH HHS UC2 AR081023NIDDK NIH HHS P30 DK043351NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation, and cancer. While coding variation in

Identifiers

PMID36993194
PMCPMC10055604
OpenAlexW4327909523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.