Evidence map›Paper›PMID 36993175›Full record

ArticlebioRxiv : the preprint server for biology2023

A beneficial adaptive role for CHOP in driving cell fate selection during ER stress.

Kaihua Liu, Chaoxian Zhao, Reed C Adajar, Diane DeZwaan-McCabe, D Thomas Rutkowski

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kaihua LiuProgram in Human Toxicology, University of Iowa Carver College of Medicine, Iowa City, IA.
Chaoxian ZhaoShanghai Cancer Institute, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Reed C AdajarDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA.
Diane DeZwaan-McCabeDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA.
D Thomas RutkowskiProgram in Human Toxicology, University of Iowa Carver College of Medicine, Iowa City, IA.
University of Iowa · USShanghai Jiao Tong University · CN

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Regulation of Fatty Acid Oxidation during ER stress: mechanisms and consequencesR01GM115424 · NIGMS · UNIVERSITY OF IOWA · PI RUTKOWSKI, DAVID THOMAS · 2015 to 2023
$2.5M
NIDDK NIH HHS P30 DK054759NIGMS NIH HHS R01 GM115424
6 · The paper itself

Abstract

Cellular stresses elicit signaling cascades that are capable of either mitigating the inciting dysfunction or initiating cell death. During endoplasmic reticulum (ER) stress, the transcription factor CHOP is widely recognized to promote cell death. However, it is not clear whether CHOP also has a beneficial role during adaptation. Here, we have combined a new, versatile, genetically modified

Identifiers

PMID36993175
PMCPMC10055232
OpenAlexW4328050945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.