ArticleJournal of family medicine and primary care2022
Evaluation of alkaline phosphatase in gingival crevicular fluid and saliva of patients with periodontitis and healthy individuals.
Article in Journal of family medicine and primary care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Association between salivary alkaline phosphatase levels and periodontal disease: a systematic review and meta-analysis.BDJ open · 2026Article
- The salivary metabolomics analyses reveal the variable metabolites in distinct staging of periodontitis.BMC oral health · 2025Article
- Association Between Severe Periodontitis and Cognitive Decline in Older Adults.Life (Basel, Switzerland) · 2024Article
- A Roadmap for the Rational Use of Biomarkers in Oral Disease Screening.Biomolecules · 2024Review
- A preliminary study on calcifying nanoparticles in dental plaque: Isolation, characterization, and potential mineralization mechanism.Clinical and experimental dental research · 2024Article
- Inflammation mediated Osteoclastogenesis and bone resorption markers in Periodontitis subjects with and without type 2 diabetes- A Cross-sectional study.Journal of oral biology and craniofacial researchArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In recent decades, biomarkers have been used to predict the progression of chronic periodontitis. One of these biomarkers is alkaline phosphatase (ALP). Due to limitations of the performed studies, this study was performed to determine the amount of salivary ALP and gingival crevicular fluid in patients with chronic periodontitis and healthy individuals. Materials and Methods: Twenty-three patients with severe chronic periodontitis and 23 healthy individuals referred to the Periodontology Department of Ahvaz Jundishapur School of Dentistry were evaluated in this analytical epidemiological study. Salivary ALP and gingival crevicular fluid (GCF) were measured using ALP measuring kit and Hitachi device. Results: Mean (standard deviation) of ALP enzyme was 19.43 (12.5) in GCF of patients with chronic periodontitis and 12 (1.48) in the healthy group, and it was 80.17 (23.9) in the saliva of patients with periodontitis and 24.78 (4.37) units per litre in the healthy group. There was a significant difference in the mean of this enzyme in GCF and saliva of patients with chronic periodontitis and healthy individuals ( Conclusion: The results showed that mean of ALP enzyme is significantly higher in GCV and saliva of patients with chronic periodontitis than in healthy individuals. Therefore, it seems that this parameter can be used as a useful biochemical parameter for the diagnosis of periodontal disease.
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