Evidence map›Paper›PMID 36992561›Full record

ArticleBiophysical journal2023

Mitocans induce lipid flip-flop and permeabilize the membrane to signal apoptosis.

Stuart R Castillo, Michael H L Nguyen, Mitchell DiPasquale, Elizabeth G Kelley, Drew Marquardt

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Membranes in focus.Biophysical journal · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Stuart R CastilloDepartment Chemistry and Biochemistry, University of Windsor, Windsor, Canada.
Michael H L NguyenDepartment Chemistry and Biochemistry, University of Windsor, Windsor, Canada.
Mitchell DiPasqualeDepartment Chemistry and Biochemistry, University of Windsor, Windsor, Canada.
Elizabeth G KelleyCenter for Neutron Research, National Institute of Standards and Technology, Gaithersburg, Maryland.
Drew MarquardtDepartment Chemistry and Biochemistry, University of Windsor, Windsor, Canada; Department of Physics, University of Windsor, Windsor, Canada. Electronic address: drew.marquardt@uwindsor.ca.
University of Windsor · CANational Institute of Standards and Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancratistatin (PST) and narciclasine (NRC) are natural therapeutic agents that exhibit specificity toward the mitochondria of cancerous cells and initiate apoptosis. Unlike traditional cancer therapeutic agents, PST and NRC are effective, targeted, and have limited adverse effects on neighboring healthy, noncancerous cells. Currently, the mechanistic pathway of action for PST and NRC remains elusive, which in part inhibits PST and NRC from becoming efficacious therapeutic alternatives. Herein, we use neutron and x-ray scattering in combination with calcein leakage assays to characterize the effects of PST, NRC, and tamoxifen (TAM) on a biomimetic model membrane. We report an increase in lipid flip-flop half-times (t

Indexed as

NeoplasmsTamoxifenApoptosisBiological TransportHumansLipid BilayersLipidsLipid BilayersLipidsTamoxifen

Identifiers

PMID36992561
PMCPMC10257148
OpenAlexW4361291800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.