Evidence map›Paper›PMID 36992533›Full record

ArticleCartilage2024

The Longer-Term Effects of a Single Bupivacaine Exposure on the Mechanical Properties of Native Cartilage Explants.

Kylie T Callan, Gaston Otarola, Wendy E Brown, Kyriacos A Athanasiou, Dean Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kylie T CallanUniversity of California, Irvine School of Medicine, Irvine, CA, USA.ORCID 0000-0001-5530-179X
Gaston OtarolaDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Wendy E BrownDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-2546-7427
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0001-5387-8405
Dean WangUniversity of California, Irvine School of Medicine, Irvine, CA, USA.ORCID 0000-0002-3005-1154
University of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine the

designFemoral condyle articular cartilage explants were aseptically harvested from juvenile bovine stifle joints before being exposed to chondrogenic medium containing 0.50% (wt/vol) bupivacaine, 0.25% (wt/vol) bupivacaine, or no medication (control) for 1 hour. Explants were then washed and maintained in culture

resultsExplants exhibited a dose-dependent decrease in mean tensile Young's modulus with increasing bupivacaine concentration (9.86 MPa in the controls, 6.48 MPa in the 0.25% bupivacaine group [

conclusionsThree weeks after 1-hour bupivacaine exposure, the tensile properties of bovine cartilage explants were significantly decreased, while the compressive properties remained unaffected. These decreases in tensile properties corresponded with reductions in collagen content and crosslinking of collagen fibers. Physicians should be judicious regarding the intra-articular administration of bupivacaine in native joints.

Indexed as

Anesthetics, LocalBupivacaineCartilage, ArticularTensile StrengthAnimalsBiomechanical PhenomenaCattleCell SurvivalCollagenCompressive StrengthDose-Response Relationship, DrugElastic ModulusAnesthetics, LocalBupivacaineCollagenbupivacainecartilagemechanicsviability

Identifiers

PMID36992533
PMCPMC11368901
OpenAlexW4361281699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.