Evidence map›Paper›PMID 36992499›Full record

ArticleViruses2023

First Expert Elicitation of Knowledge on Possible Drivers of Observed Increasing Human Cases of Tick-Borne Encephalitis in Europe.

Claude Saegerman, Marie-France Humblet, Marc Leandri, Gaëlle Gonzalez, Paul Heyman, Hein Sprong, Monique L'Hostis, Sara Moutailler, Sarah I Bonnet, Nadia Haddad and 34 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
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  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. One health in the Arctic - connections and actions.International journal of circumpolar health · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Tick exposure biomarkers: A One Health approach to new tick surveillance tools.Current research in parasitology & vector-borne diseases · 2024
    Article
  16. Review
  17. Tick-Borne Encephalitis Virus andPathogens (Basel, Switzerland) · 2023
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 15 countries.

Claude SaegermanFundamental and Applied Research for Animal and Health (FARAH) Center, University of Liege, 4000 Liege, Belgium.ORCID 0000-0001-9087-7436
Marie-France HumbletDepartment for Occupational Protection and Hygiene, Unit Biosafety, Biosecurity and Environmental Licences, University of Liege, 4000 Liege, Belgium.ORCID 0000-0003-4069-9402
Marc LeandriUMI SOURCE, Université Paris-Saclay-UVSQ, 78000 Versailles, France.ORCID 0000-0002-5939-2403
Gaëlle GonzalezANSES, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR VIROLOGIE, Laboratoire de Santé Animale, 94700 Maisons-Alfort, France.ORCID 0000-0003-4805-7316
Paul HeymanHoogstraat 159/5, 3665 As, Belgium.
Hein SprongCentre for Infectious Disease Control, National Institute for Public Health and the Environment, 3720 MA Bilthoven, The Netherlands.ORCID 0000-0002-0218-4320
Monique L'HostisEcole Nationale Vétérinaire Agroalimentaire et de l'Alimentation Nantes-Atlantique, Oniris, 44307 Nantes, France.
Sara MoutaillerANSES, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700 Maisons-Alfort, France.ORCID 0000-0003-3010-6968
Sarah I BonnetUMR 2000 Institut Pasteur-CNRS-Université Paris-Cité, Ecology and Emergence of Arthropod-borne Pathogens, 75015 Paris, France.ORCID 0000-0002-6365-6117
Nadia HaddadANSES, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700 Maisons-Alfort, France.
Nathalie BoulangerUR7290: VBP: Borrelia Group, France and French Reference Centre on Lyme Borreliosis, CHRU, Unversity of Strasbourg, 67000 Strasbourg, France.
Stephen L LeibInstitute for Infectious Diseases, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0002-1106-6123
Thierry HochOniris, INRAE, BIOEPAR, 44300 Nantes, France.ORCID 0000-0002-7916-1936
Etienne ThiryFundamental and Applied Research for Animal and Health (FARAH) Center, University of Liege, 4000 Liege, Belgium.ORCID 0000-0002-9585-7933
Laure BournezANSES, Nancy Laboratory for Rabies and Wildlife, 54220 Malzéville, France.
Jana KerlikDepartment of Epidemiology, Regional Authority of Public Health in Banská Bystrica, 497556 Banská Bystrica, Slovakia.
Aurélie VelayUnité Mixte de Recherché Immunorhumathologie Moléculaire (UMR IRM_S) 1109, Université de Strasbourg, INSERM, 67000 Strasbourg, France.
Solveig JoreZoonotic, Water and Foodborne Infections, The Norwegian Institute for Public Health (NIPH), 0213 Oslo, Norway.
Elsa JourdainUniversité Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Route de Theix, 63122 Saint-Genès-Champanelle, France.
Emmanuelle Gilot-FromontUniversité de Lyon, VetAgro Sup, UMR CNRS 5558, Marcy-l'Etoile, 69280 Lyon, France.ORCID 0000-0003-0011-7519
Katharina BruggerCompetence Center Climate and Health, Austrian National Institute of Public Health, 1010 Vienna, Austria.ORCID 0000-0002-7327-4841
Julia GellerDepartment of Virology and Immunology, National Institute for Health Development, 11619 Tallinn, Estonia.ORCID 0000-0001-6496-9687
Marie StudahlInstitute of Biomedicine, Department of Infectious Diseases, University of Gothenburg, 41685 Gothenburg, Sweden.
Nataša KnapInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška cesta 4, 1000 Ljubljana, Slovenia.
Tatjana Avšič-ŽupancInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška cesta 4, 1000 Ljubljana, Slovenia.ORCID 0000-0001-6243-0688
Daniel RůžekInstitute of Parasitology, Biology Centre of the Czech Academy of Sciences, 37005 Ceske Budejovice, Czech Republic.ORCID 0000-0003-4655-2380
Tizza P ZomerLyme Center Apeldoorn, Gelre Hospital, 7300 DS Apeldoorn, The Netherlands.
René BødkerAnimal Welfare and Disease Control, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.
Thomas F H BergerAgroscope, Risk Evaluation and Risk Mitigation, Schwarzenburgstrasse, 3003 Bern-Liebefeld, Switzerland.ORCID 0000-0002-7452-5358
Sandra Martin-LatilLaboratory for Food Safety, ANSES, University of Paris-EST, 94700 Maisons-Alfort, France.
Nick De ReggeOperational Direction Infectious Diseases in Animals, Unit of Exotic and Vector-borne Diseases, Sciensano, 1180 Brussels, Belgium.
Alice RaffetinReference Centre for Tick-Borne Diseases, Paris and Northern Region, Department of Infectious Diseases, General Hospital of Villeneuve-Saint-Georges, 94100 Villeneuve-Saint-Georges, France.ORCID 0000-0002-5003-540X
Sandrine A LacourANSES, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR VIROLOGIE, Laboratoire de Santé Animale, 94700 Maisons-Alfort, France.
Matthias KleinNeurologische Klinik und Poliklinik, Klinikum der Universität München, LMU München, Marchioninistraße 15, 81377 München, Germany.
Tinne LernoutScientific Directorate of Epidemiology and Public Health, Sciensano, 1180 Brussels, Belgium.
Elsa QuilleryANSES, Risk Assessment Department, 94700 Maisons-Alfort, France.
Zdeněk HubálekInstitute of Vertebrate Biology, Czech Academy of Sciences, Květná 8, 60365 Brno, Czech Republic.
Francisco Ruiz-FonsHealth & Biotechnology (SaBio) Group, Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC-UCLM-JCCM, 13071 Ciudad Real, Spain.ORCID 0000-0002-0820-5292
Agustín Estrada-PeñaDeptartment of Animal Health, Faculty of Veterinary Medicine, 50013 Zaragoza, Spain.ORCID 0000-0001-7483-046X
Philippe FravaloPôle Agroalimentaire, Conservatoire National des Arts et Métiers (Cnam), 75003 Paris, France.
Pauline KoohANSES, Risk Assessment Department, 94700 Maisons-Alfort, France.
Florence EtoreANSES, Risk Assessment Department, 94700 Maisons-Alfort, France.
Céline M GossnerEuropean Centre for Disease Prevention and Control (ECDC), 17183 Solna, Sweden.ORCID 0000-0001-9345-5511
Bethan PurseUK Centre for Ecology & Hydrology, Benson Lane, Crowmarsh Gifford, Oxfordshire OX10 8BB, UK.
École Nationale Vétérinaire d'Alfort · FRAgence Nationale des Fréquences · FRUniversity of Liège · BESciensano (Belgium) · BEUniversity of Ljubljana · SIAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail · FRAgroscope · CHCentre National de la Recherche Scientifique · FRConservatoire National des Arts et Métiers · FRCzech Academy of Sciences, Institute of Vertebrate Biology · CZGelre Hospitals · NLGesundheit Österreich · ATHôpitaux Universitaires de Strasbourg · FRInserm · FRInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRInstituto de Investigación en Recursos Cinegéticos · ESLMU Klinikum · DEMaastricht University Medical Centre · NLMasaryk University · CZNational Institute for Health Development · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-borne encephalitis (TBE) is a viral disease endemic in Eurasia. The virus is mainly transmitted to humans via ticks and occasionally via the consumption of unpasteurized milk products. The European Centre for Disease Prevention and Control reported an increase in TBE incidence over the past years in Europe as well as the emergence of the disease in new areas. To better understand this phenomenon, we investigated the drivers of TBE emergence and increase in incidence in humans through an expert knowledge elicitation. We listed 59 possible drivers grouped in eight domains and elicited forty European experts to: (i) allocate a score per driver, (ii) weight this score within each domain, and (iii) weight the different domains and attribute an uncertainty level per domain. An overall weighted score per driver was calculated, and drivers with comparable scores were grouped into three terminal nodes using a regression tree analysis. The drivers with the highest scores were: (i) changes in human behavior/activities; (ii) changes in eating habits or consumer demand; (iii) changes in the landscape; (iv) influence of humidity on the survival and transmission of the pathogen; (v) difficulty to control reservoir(s) and/or vector(s); (vi) influence of temperature on virus survival and transmission; (vii) number of wildlife compartments/groups acting as reservoirs or amplifying hosts; (viii) increase of autochthonous wild mammals; and (ix) number of tick species vectors and their distribution. Our results support researchers in prioritizing studies targeting the most relevant drivers of emergence and increasing TBE incidence.

Indexed as

DermacentorEncephalitis, Tick-BorneIxodesAnimalsAnimals, WildEuropeHumansMammalsclustering analysisDermacentor reticulatusdriversexpert elicitationflavivirusgenus Ixodesmulti-criteria decision analysis (MCDA)sensitivity analysisTBEVtick-borne encephalitis (TBE)ticksuncertainty

Identifiers

PMID36992499
PMCPMC10054665
OpenAlexW4327951981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.