Evidence map›Paper›PMID 36992490›Full record

ReviewViruses2023

The Role of Viral Infections in the Onset of Autoimmune Diseases.

Bhargavi Sundaresan, Fatemeh Shirafkan, Kevin Ripperger, Kristin Rattay

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
50.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 161 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bhargavi SundaresanInstitute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, 35043 Marburg, Germany.ORCID 0000-0002-6732-0880
Fatemeh ShirafkanInstitute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, 35043 Marburg, Germany.ORCID 0000-0002-0931-1468
Kevin RippergerInstitute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, 35043 Marburg, Germany.ORCID 0000-0001-8173-9533
Kristin RattayInstitute of Pharmacology, Biochemical Pharmacological Center, University of Marburg, 35043 Marburg, Germany.ORCID 0000-0003-3503-2136
Philipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to the inability to sufficiently differentiate between self and non-self. Immune reactions that are targeted towards self-antigens can ultimately lead to the destruction of the host's cells and the development of autoimmune diseases. Although autoimmune disorders are comparatively rare, the worldwide incidence and prevalence is increasing, and they have major adverse implications for mortality and morbidity. Genetic and environmental factors are thought to be the major factors contributing to the development of autoimmunity. Viral infections are one of the environmental triggers that can lead to autoimmunity. Current research suggests that several mechanisms, such as molecular mimicry, epitope spreading, and bystander activation, can cause viral-induced autoimmunity. Here we describe the latest insights into the pathomechanisms of viral-induced autoimmune diseases and discuss recent findings on COVID-19 infections and the development of AIDs.

Indexed as

Autoimmune DiseasesCOVID-19Virus DiseasesAutoantigensAutoimmunityHumansAutoantigensautoimmunitybystander activationcentral toleranceCOVID-19epitope spreadingmolecular mimicrymultiple sclerosisperipheral tolerancerheumatoid arthritissystemic lupus erythematosustype 1 diabetes

Identifiers

PMID36992490
PMCPMC10051805
OpenAlexW4327962983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.